Плохой аппетит как признак железодефицита у детей первых лет жизни

[Dr.Vad]

Одной из причин плохого аппетита у детей первых лет жизни может быть железодефицит или ЖД анемия, похоже, что это связано со сниженной продукцией грелина, коррекция ЖД препаратами ведет к улучшению аппетита и увеличению обьема сьедаемой пищи:

One of the well-known clinical features of iron-deficiency anemia is poor appetite....24 infants and small children (mean age +/- standard deviation = 19.6 +/- 7.7 months) with iron deficiency.... After 15.0 +/- 2.4 wk of iron treatment, serum ferritin levels improved significantly, with accompanying increases in their subjective appetite scores and food intakes.... ferritin correlated significantly with appetite score (r = 0.680, P < 0.001) and food intake (r = 0.480, P < 0.01).//Nutrition. 2001 Jul-Aug;17(7-8):657-9.

A significant positive correlation was demonstrated between iron status of the body and levels of ghrelin. Decrease in ghrelin levels in IDA can lead to loss of appetite, desire to eat diverse foods with resultant delay in growth and development.//J Pediatr Hematol Oncol. 2007 Jun;29(6):384-7

...low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.//Endocr J. 2007;54(6):985-90.