Железодефицитные новости

[Dr.Vad]

Редкое употребление красного мяса, но не птицы, ассоциируется с повышенным (4-х кратным) повышением риска развития анемии в детском возрасте:

J Pediatr Gastroenterol Nutr. 2013 Dec;57(6):722-7.
Anemia and iron deficiency in children: association with red meat and poultry consumption.
Moshe G, Amitai Y, Korchia G, Korchia L, Tenenbaum A, Rosenblum J, Schechter A.
Department of Management, Health Systems Management Program, Bar Ilan University, Ramat Gan Meuhedet Health Services Hadassah University Mt Scopus, Jerusalem, Israel.

OBJECTIVE: The aim of this study was to study the relative contribution of dietary sources of iron in children with high prevalence of anemia and iron deficiency (ID).

METHODS: A cross-sectional study in 263 healthy, 1.5- to 6-year-old children in the Jewish sector of Jerusalem, Israel. Venous blood samples and a qualitative Food Frequency Questionnaire on iron-rich foods were obtained. Anemia was defined as hemoglobin <11 g/dL for children younger than 4 years and <11.5 g/dL for children older than 4 years; ID was defined as ferritin <12 μg/L.

RESULTS: Anemia was found in 11.2%, ID in 22%, and iron-deficiency anemia in 3.7%. The prevalence of anemia was higher in toddlers ages 1.5 to 3 years compared with children ages 3 to 6 years (17.7% vs 7.3%, P = 0.01). Children with extremely low red meat consumption (seldom) had 4-fold higher rates of ID than those who consumed ≥2 times per week (odds ratio 3.98; 95% confidence interval 1.21-13.03; P = 0.023), whereas poultry consumption was not associated with ID. Soy consumption was inversely associated with ferritin (marginally significant, r = -0.134, P = 0.057).

CONCLUSIONS: The high prevalence of anemia and ID found in this study, mainly in children 1.5 to 3 years old, is related to low red meat consumption. The characteristically high poultry consumption in the Israeli population was not protective. The shift toward reduced red meat consumption and higher poultry consumption in developed countries may result in increasing the risk of ID.

[Dr.Vad]

Недавнее описание клинического случая длительной лейкопении (доброкачественной нейтропении) на фоне ЖДА, когда коррекция железодефицита привела к восстановлению нормального числа лейкоцитов/нейтрофилов:

Int J Clin Pharm. 2013 Dec 18.
Unexplained chronic leukopenia treated with oral iron supplements.
Abuirmeileh A, Bahnassi A, Abuirmeileh A.
Internal Medicine, Isawiya Medical Center, Amman, Jordan.

Case A 67-year-old woman known to have iron deficiency anemia and persistent unexplained chronic leukopenia was cared for by our medical center for about 16 years. During this period she was examined thoroughly and diagnosed to have chronic idiopathic neutropenia (also known as chronic benign neutropenia). Her iron deficiency was attributed to nutritional factors and she was non-compliant with her oral iron supplements. The patient fully received her iron supplement medication by nursing staff for two and a half months during an unexpected prolonged hospital stay after her suffering an acute ischemic cerebrovascular accident. An astonishing outcome was that in addition to having her iron deficiency anemia treated, her long-term unexplained neutropenia was also corrected. Conclusion Some patients diagnosed with chronic idiopathic neutropenia and clinically present as having unexplained chronic neutropenia might actually be suffering from a form of not yet described iron deficiency induced neutropenia.

[Dr.Vad]

Презентация клинического случая синдрома беспокойных ног у женжины с избыточным весом и нормальным ферритином: диагноз дефицита железа был заподозрен клинически и подтвержден с помощью низкой сатурации трансферрина железом (железо/ОЖСС менее 20%):

J Clin Sleep Med. 2013 May 15;9(5):511-3.
Normal ferritin in a patient with iron deficiency and RLS.
Mackie S, Winkelman JW.
[Ссылки доступны только зарегистрированным пользователям ]

[Dr.Vad]

Дефицит железа (насыщение трансферрина железом менее 24%) как и его избыток (насыщение трансферрина железом более 40%) ассоциируются с повышенной смертностью у людей в том числе и от сердечно-сосудистых заболеваний:

Both low and high TSAT ratios are significantly and independently associated with increased total and cardiovascular mortality. The optimal TSAT ratio associated with the greatest survival is between 24% and 40%.
--
Stack AG и соавт. Transferrin Saturation Ratio and Risk of Total and Cardiovascular Mortality in the General Population. QJM. 2014 Mar 5.

[Ссылки доступны только зарегистрированным пользователям ]

[Dr.Vad]

Experience with intravenous ferric carboxymaltose in patients with iron deficiency anemia
[Ссылки доступны только зарегистрированным пользователям ]

[Dr.Vad]

Публикация из Турции показывает, что вслед за коррекцией ЖДА у женщин улучшились показатели по шкале тревожности Бека и индексу сексуальной оценки (Beck Anxiety Inventory, Female Sexual Function Index), в то время как качество жизни осталось прежним:

J Sex Med. 2014 Apr;11(4):1042-6.
Impact of iron supplementation on sexual dysfunction of women with iron deficiency anemia in short term: a preliminary study.
Gulmez H, Akin Y, Savas M, Gulum M, Ciftci H, Yalcinkaya S, Yeni E.
Author information Department of Family Medicine, Public Health Institution of Turkey, Konya, Turkey.

INTRODUCTION: Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide. It is an important health problem especially in women of reproductive age. IDA may cause anxiety, which is the major factor for female sexual dysfunction (FSD).

AIM: The aim of the present study was to determine the impact of IDA on FSD in women of reproductive age.

METHODS: In total, 207 women were enrolled. Women with IDA who were admitted in an outpatient clinic of family medicine were asked to complete Beck Anxiety Inventory (BAI), Female Sexual Function Index (FSFI), and Quality of Life (QoL) questionnaires. Questionnaires were completed before and after IDA treatments. Blood samples were obtained for measurements of hemoglobin, hematocrit, levels of serum iron, and iron-binding capacity.

MAIN OUTCOME MEASURES: Outcomes of blood samples were used for diagnosing of IDA. BAI, FSFI, and QoL scores were evaluated. Paired samples t-tests and Pearson correlation analyses were used to assess relationship between findings of IDA treatments and other parameters.

RESULTS: The mean age was 33.6 ± 8.4 years. There were statistical significant differences between pre- and posttreatment in terms of hemoglobin, hematocrit, serum iron, and serum iron-binding capacity. BAI scores were decreased and FSFI scores, which were statistically significant, increased after IDA treatments (P < 0.001). However, QoL scores were developed without statistical significance.

CONCLUSION: There is a risk for anxiety as well as FSD in IDA women of reproductive age. Treatment of IDA can significantly improve sexual functions and QoL in these women population in short term.

[Dr.Vad]

Железодефицит у молодых японок ассоциируется с более высокими индексами утомляемости, напряжения и гнева, похоже, что более высокое потребление зеленого чая с витамином С препятствует развитию анемизации (снижению гемоглобина менее 120 г/л) у них:

Biol Trace Elem Res. 2014 Apr 23.
Iron Deficiency Without Anemia Is Associated with Anger and Fatigue in Young Japanese Women.
Sawada T, Konomi A, Yokoi K.
Faculty of Food and Nutritional Sciences, Toyo University, Gunma, Japan.

Iron deficiency without anemia (IDNA), the most prevalent nutritional deficiency worldwide, affects young women of reproductive age. This study aimed to elucidate the relationship between IDNA and mental and somatic symptoms including anger and fatigue using the Japanese version of the Cornell Medical Index Health Questionnaire (CMI-J). Data regarding demographic characteristics, anthropometry, hematological, and biochemical indices of the iron status, frequencies of selected food intakes assessed by self-administered food frequency questionnaires (FFQs), frequencies of nonspecific symptoms, and grades of neurotic tendencies assessed by CMI-J were collected from 76 young women aged 18-22 years living in the metropolitan area of Tokyo, Japan. The subjects were classified as having IDNA (hemoglobin (Hb) ≥ 12 g/dL and serum ferritin < 20 ng/mL; n = 29), having iron deficiency anemia (IDA) (Hb < 12 g/dL and serum ferritin < 20 ng/mL; n = 10), or having a normal iron status (Hb ≥ 12 g/dL and serum ferritin ≥ 20 ng/mL; n = 36). One subject was excluded from the analyses because of Hb < 12 g/dL and serum ferritin ≥ 20 ng/mL. Fisher's protected least significant difference and the Dwass-Steel-Chritchlow-Fligner multiple comparison tests were used to compare the data of the three groups. P values <0.05 were considered significant. Sections M-R (mental complaints) were significantly higher in the IDNA subjects than in the normal subjects. No significant difference in CMI scores was found between the normal and IDA subjects. Sections I (fatigability), Q (anger), and R (tension) were significantly higher in the IDNA subjects than in the normal subjects, regardless of no significant differences between the normal and IDA subjects in those sections. Young women with IDNA demonstrated a significantly higher proportion of neurotic tendencies (grades II-IV). The intake frequency score of canned or bottled green tea fortified with vitamin C was significantly higher in the IDNA subjects than the IDA subjects. The findings suggest that IDNA may be a risk factor for anger, fatigue, and tension in women of childbearing age.