Снижение веса диетой и ремиссия диабета 2 типа

[Dr.Vad]

Похоже, эта публикация прошла незамеченной - в ланцете опубликовали британское исследование, как снижение веса диетой приводит к ремиссии СД2:

Diabetes remission was achieved in 68 (46%) participants in the intervention group and 6 (4%) participants in the control group (odds ratio 19·7, 95% CI 7·8-49·8; p<0·0001).

Remission varied with weight loss in the whole study population, with achievement in
0 of 76 participants who gained weight,
6 (7%) of 89 participants who maintained 0-5 kg weight loss,
19 (34%) of 56 participants with 5-10 kg loss,
16 (57%) of 28 participants with 10-15 kg loss, and
31 (86%) of 36 participants who lost 15 kg or more.
---
Lancet. 2018 Feb 10;391(10120):541-551.
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.
[Ссылки доступны только зарегистрированным пользователям ]

Подробности набора пациентов и их начальные метаболические параметры здесь:

Of 1510 people invited, 423 (28%) accepted; of whom, 306 (72%) were eligible at screening and gave informed consent. Seven participants were later found to have been randomised in error and one withdrew consent, leaving 298 (176 men, 122 women) who will form the intention to treat (ITT) population for analysis. Mean (SD) age was 54.4 (7.6) years, duration of diabetes 3.0 (1.7) years, BMI 34.6 (4.4) kg/m2 for all participants (34.2 (4.2) kg/m2 in men and 35.3 (4.6) kg/m2 in women) and baseline HbA1c (on treatment) 59.3 (12.7) mmol/mol (7.6% [1.2%]).
[Ссылки доступны только зарегистрированным пользователям ]