diagnosis of Cushing’s disease

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The usefulness of combined biochemical tests in the diagnosis of Cushing’s disease with negative pituitary magnetic resonance imaging

CLINICAL STUDY
European Journal of Endocrinology, Vol 156, Issue 2, 241-248

Objective: The etiological diagnosis of ACTH-dependent Cushing’s syndrome is often a problem. In fact, no endocrine or radiological examination can conclusively distinguish the ectopic from the pituitary source of disease. The aim of our study was to evaluate the role of stimulation and suppression endocrine tests in the diagnostic and therapeutic approach of patients with Cushing’s disease (CD) and negative pituitary magnetic resonance imaging (MRI), considering their post-surgical outcome in comparison with patients with CD and positive MRI.
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