#31
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Öèòàòà:
À íàñ÷åò ïðîèñõîæäåíèÿ ìèòîõîíäðèé - äà, åñòü òàêàÿ ãèïîòåçà, è âïîëíå îáîñíîâàííàÿ. |
#32
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Ñåé÷àñ ïîñìîòðåëà âíèìàòåëüíåå öèòàòó èç basic. ×òî òàêîå àòèïè÷íûå íèçêîìåòàáîëè÷åñêèå òðèõîìîíàäû, ìíå íå èçâåñòíî. È êàê îíè ìîäèôèöèðóþòñÿ â òèïè÷íûå íîðìàëüíîìåòàáîëè÷åñêèå? (Ïðîñòèòå, åñëè èñêàæàþ òåðìèíîëîãèþ ïåðâîèñòî÷íèêà, íî ýòî ÷òî-òî î÷åíü íîâîå è îðèãèíàëüíîå). Êòî-íèáóäü èìååò îá ýòîì èíôîðìàöèþ, ïîìèìî êóñêà ýòèõ òåçèñîâ?
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#33
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Öèòàòà:
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#34
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À ïî÷åìó îáÿçàòåëüíî â Microbiology?  ïî÷èâøåé áàçå BioMedNet áûëî äîñòàòî÷íî ññûëîê íà ñòàðûå ðàáîòû ñ ÝÌ, èç ñâåæåíüêîãî:
Infect Immun. 2005 Feb;73(2):1180-6. Long-term survival and intracellular replication of Mycoplasma hominis in Trichomonas vaginalis cells: potential role of the protozoon in transmitting bacterial infection. Dessi D, Delogu G, Emonte E, Catania MR, Fiori PL, Rappelli P. Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale S. Pietro 43/B, 07100 Sassari, Italy. In this work, we examined the cellular location of M. hominis in respect to T. vaginalis. By using gentamicin protection assays, double immunofluorescence, and confocal microscopy, we obtained strong evidence that M. hominis is located within protozoan cells. 5-Bromodeoxyuridine incorporation assays showed that intracellularly located mycoplasmas actively synthesize DNA. Our results demonstrate that M. hominis has the capability of entering trichomonad cells and of replicating inside the protozoon. These findings suggest that symbiosis might provide the bacteria, during human infection, with the capability to resist to environmental stresses, such as host defense mechanisms and pharmacological therapies. Arch Microbiol. 2001 Jan;175(1):70-4. Mycoplasma hominis and Trichomonas vaginalis symbiosis: multiplicity of infection and transmissibility of M. hominis to human cells. Rappelli P, Carta F, Delogu G, Addis MF, Dessi D, Cappuccinelli P, Fiori PL. Department of Biomedical Sciences, University of Sassari, Italy. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] We recently reported that most Trichomonas vaginalis isolates cultured in vitro are infected by Mycoplasma hominis. In this work, we have characterized some aspects of the relationships between the two microorganisms. PCR, cultivation, and immunological methods revealed that the number of M. hominis organisms carried by T. vaginalis in culture varied from isolate to isolate, suggesting a specific multiplicity of infection. Moreover, infected T. vaginalis isolates were able to pass bacteria not only to M. hominis-free protozoa, but also to human-derived epithelial cells. The in vitro transmission of the bacterium from T. vaginalis to both uninfected parasite isolates and human epithelial cells suggests a role for T. vaginalis as a carrier of the M. hominis infection in vivo. Òàê ÷òî, ïî ïîñëåäíèì äàííûì, îíè òàì åùå è ðàçìíîæàþòñÿ. |
#35
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Öèòàòà:
Íå ïîÿñíèòå ëè â äâóõ ñëîâàõ ÷òî òàêîå "gentamicin protection assays" è "double immunofluorescence".  ïîñëåäíåì ñëó÷àå, âèäèìî, ðå÷ü èäåò îá èñïîëüçîâàíèè äâóõ âèäîâ àíòèòðèõîìîíàäíûõ àíòèòåë ìå÷åíûõ ÔÈÒÖ? È åùå... Êàê Âû îòíîñèòåñü ê ðàáîòàì ïðîô. Äìèòðèåâà Ã.À., îáíàðóæèâøåãî ÂÏÃ-1,2 â ãîíîêîêêå? |
#36
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Öèòàòà:
"double immunofluorescence" - íåò, èñïîëüçîâàëè ìå÷åíûå àíòèòåëà ê ìèêîïëàçìàì äëÿ èõ âèçóàëèçàöèè â òðèõîìîíàäàõ. Íàñ÷åò ðàáîò Äìèòðèåâà íè÷åãî íå ñêàæó, ÿ âñå-òàêè òîëüêî ïàðàçèòîëîã,à íå ìèêðîáèîëîã. |
#37
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Öèòàòà:
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#38
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Âàæíîå äîïîëíåíèå
Öèòàòà:
Ñ÷èòàþ íåîáõîäèìûì óòî÷íèòü, ÷òî äàëåêî íå âî âñåõ èññëåäîâàíèÿõ âîçìîæíîñòü ñóùåñòâîâàíèÿ öèòîáèîöåíîçà â òðèõîìîíàäàõ áûëà ïîêàçàíà. Åñòü èññëåäîâàíèÿ, â êîòîðûõ òðèõîìîíàäû ïðîñòî ïîåäàëè ýòè áàêòåðèè áåçî âñÿêîãî ïåðåõîäà ïîñëåäíèõ â öèòîïëàçìó. Ïî ýòîìó ïîâîäó áûëî îïóáëèêîâàíî, åñëè íå îøèáàþñü, â "Ëàíöåòå" çà 1999ã. ïèñüìî Ä-ðà Òåéëîð-Ðîáèíñîíà, êîòîðûé îòðèöàåò ñóùåñòâîâàíèå òàêîãî ôåíîìåíà. Ó ìåíÿ â ñòàðûõ äàóíëîäàõ åñòü åãî ðàáîòà (BR.J.Vener.Dis.,1984, 60:31-38), ãäå îí ïîêàçûâàåò îòñóòñòâèå ýòîãî ÿâëåíèÿ.  òî æå âðåìÿ íåëüçÿ èãíîðèðîâàòü áîëüøîå ÷èñëî èññëåäîâàíèé, â êîòîðûõ ýòî ÿâëåíèå äîêàçàíî. Ïîêà íèêòî íå îáúÿñíèë, ïî÷åìó ðàçíûå èññëåäîâàòåëè ïîëó÷àþò ðàçíûå äàííûå. Ìîè ñîáñòâåííûå, ÷èñòî ñïåêóëÿòèâíûå, ïðåäïîëîæåíèÿ: â ðàçíûõ ðàáîòàõ èñïîëüçîâàëèñü ðàçíûå êóëüòóðû ñ íàñëåäñòâåííî ðàçíûìè ñâîéñòâàìè òðèõîìîíàä. Âåðîÿòíî, òðèõîìîíàäû îäíèõ ëèíèé ïîä âîçäåéñòâèåì ýòèõ áàêòåðèé ñïîñîáíû ïðîïóñêàòü èõ â öèòîïëàçìó (è íå ïðîñòî ïðîïóñêàòü, à åùå è îáðàçîâûâàòü âîêðóã íèõ ñïåöèàëüíóþ çàùèòíóþ ìåìáðàíó), à äðóãèå íåò. Âîçìîæíàÿ àíàëîãèÿ: ëþäè - íîñèòåëè îïðåäåëåííûõ ãåíîâ â ãåòåðîçèãîòå (â ãîìîçèãîòå - ñìåðòåëüíûå áîëåçíè êðîâè) èìåþò ýðèòîöèòû ñ ìåìáðàíîé, óñòîé÷èâîé ê âîçäåéñòâèþ ìàëÿðèéíîãî ïëàçìîäèÿ è ïîýòîìó íåñïîñîáíûå ê èíäóöèðîâàííîìó ôàãîöèòîçó. Ïîýòîìó îíè íå áîëåþò ìàëÿðèåé. Ïî ïîâîäó àìåáîèäíûõ òðèõîìîíàä ÿ íàïèñàëà â ðàçäåëå "Ëàáîðàòîðíûå èññëåäîâàíèÿ" - áûëî ïðåäëîæåíèå îáñóæäàòü ýòó ïðîáëåìó òàì. |
#39
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ß â ñâîå âðåìÿ îòñíÿë ìèêðîâèäåîðîëèê ïîäîáíîãî "ïîåäàíèÿ". Òðèõîìîíàäû âåðòÿò æãóòèêàìè òàê, ÷òî ñîçäàåòñÿ äâèæåíèå æèäêîñòè íà ïîäîáèå âîðîíêè. Áëèçêî íàõîäÿùèõñÿ áàêòåðèé ïðÿìî "çàñàñûâàåò" â òàêóþ âîðîíêó. Ìíîãèì áàêòåðèÿì, êîíå÷íî, óäàåòñÿ âûðâàòüñÿ èç ýòîãî "âîäîâîðîòà", íî íåêîòîðûå ïîïàäàþò âîâíóòðü . Î÷åíü ÷àñòî ïîòîì èõ âèäíî âíóòðè öèòîïëàçìû òðèõîìîíàä.
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#40
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Çàøëà ñïåöèàëüíî îòìåòèòüñÿ. Ñäàëà åùå ðàç àíàëèçû. Âñå ÷èñòî! Óðà! Ò.å. è íàòèâíûé ìàçîê íå ïîêàçàë òðèõîìîíàä è ÏÖÐ òîæå íå íàøåë íå èõ íå õëàìèäèé. À áûë ëè ìàëü÷èê?
Ãëàâíîå, ÷òî âñå, ê ñ÷àñòüþ, ïîçàäè. Âñåì áîëüøîå ñïàñèáî çà îòêëèêè! |
#41
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Çäðàâñòâóéòå. Ïîìîãèòå ïîæàëóéñòà! Ïîñòàâèëè äèàãíîç òðèõîìîíèàç. Âðà÷ íàçíà÷èë ëå÷åíèå: öèêëîôåðîí, òèáåðàë, ôëóêîíàçîë, òðèïñèí. Ïðèîáðåë ýòè ëåêàðñòâà, íî â îïèñàíèè ê òèáåðàëó íàïèñàíî ñëåäóùåå:
Ïðîòèâîïîêàçàíèÿ: Ãèïåð÷óâñòâèòåëüíîñòü, áåðåìåííîñòü (I òðèìåñòð), ïåðèîä ëàêòàöèè, çàáîëåâàíèÿ ÖÍÑ. Ïîáî÷íûå äåéñòâèÿ: Ãîëîâíàÿ áîëü, ãîëîâîêðóæåíèå, íàðóøåíèå ñîçíàíèÿ, òðåìîð, ðèãèäíîñòü, äèñêîîðäèíàöèÿ äâèæåíèé, ñóäîðîãè, ñåíñîðíàÿ èëè ñìåøàííàÿ ïåðèôåðè÷åñêàÿ íåâðîïàòèÿ, òîøíîòà, ðâîòà, äèàðåÿ.Ïåðåäîçèðîâêà. Ñèìïòîìû: ýïèëåïòèôîðìíûå ñóäîðîãè, äåïðåññèÿ, ïåðèôåðè÷åñêèé íåâðèò. Ëå÷åíèå: ñèìïòîìàòè÷åñêîå (äèàçåïàì - ïðè ñóäîðîãàõ). 4 ãîäà íàçàä ó ìåíÿ áûëà ñåðüåçíàÿ ×ÌÒ. Áûëà îïàñíîñòü ñóäîðîã è ÿ äîëãîå âðåìÿ ïðèíèìàë ïðîòèâîñóäîðîæíûå ïðåïàðàòû. Âîò óæå äâà ãîäà íè÷åãî íå áåñïîêîèëî. Òåïåðü áîþñü ÷òî èç-çà òèáåðàëà ìîãóò íà÷àòüñÿ ñóäîðîãè. ×òî äåëàòü? Ìîæíî ëè â òàêîé ñèòóàöèè ïðèíèìàòü òèáåðàë? |
#42
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Ëó÷øå ïîñîâåòóéòåñü ïðåäâàðèòåëüíî ñ íåâðîïàòîëîãîì. Âîçìîæíî îí íàçíà÷èò ïðåâåíòèâíîå ëå÷åíèå (ôèíëåïñèí èëè ÷òî-ëèáî äðóãîå)
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#43
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Òðèõîìîíèàç?
Ïðîêîìåíòèðóéòå ïîæàëóñòà. Âñå ýòè ìàçêè îäíîãî ïàöèåíòà.
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#44
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Öèòàòà:
2. ñîçäàåì ñâîþ òåìó. 3. Ïðåäñòàâëÿåìñÿ (âðà÷, ïàöèåíò, ñîñåä ïàöèåíòà...) 4. Îïèñûâàåì êëèíè÷åñêèé ñëó÷àé (ïî ïðàâèëàì) 5. È âîò òîãäà óæå ïðèêðåïëÿåì ñíèìêè. À òî, ïðàâî, çà÷åò ïî ëàáîðàòîðíîé äèàãíîñòèêå ïîëó÷àåòñÿ.
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Ñ óâàæåíèåì, Âàëåðèé Âàëåðüåâè÷ Ñàìîéëåíêî |
#45
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Òðèõîìîíèàç-õëàìèäèîç
Âîçìîæíî ëè èçëè÷åíèè õëàìèäèîçà áåç èçëå÷åíèÿ òðèõîìîíèàçà? Åñòü ëè ïðàêòè÷åñêèå ñëó÷àè îòñóöòâèÿ ðåöèäèâîâ ïåðâîãî?
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