Не-нулевая группа крови как фактор риска возникновения венозного тромбоза

[Dr.Vad]

Наличие второй, третьей, четвертой группы крови у индивида повышает риск развития венозного тромбоза примерно настолько, как и тромбофилические (фактор 5 Лейден, мутация протромбина, дефицит натуральных антикоагулянтов) факторы риска.

...systematic review 38 studies with 10,305 VTE cases. The prevalence of non-O blood group was significantly higher in VTE patients compared with controls with a resulting pooled odds ratio (OR) of 2.09 (95% confidence interval [CI], 1.83, 2.38; p < 0.00001). The maximum VTE risk was observed in non-O-factor V Leiden patients (OR 7.60, 95% CI, 3.21, 17.99), while for G20210A prothrombin mutation it was not possible to perform a pooled analysis due to a paucity of published studies... non-O blood group is a candidate to be one of the most important genetic risk factors for venous thrombosis.

Semin Thromb Hemost. 2012 Jul;38(5):535-48.
Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature.
Dentali F и соавт.

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A non-O blood group was present in 492 cases and 358 controls (OR 2.21; 95% CI, 1.78 to 2.75). A thrombophilic abnormality was present in 237 cases and 105 controls (OR 2.82; 2.18 to 3.66). The combination of non-O group and thrombophilia was present in 152 cases and 51 controls (OR 7.06; 4.85 to 10.28).
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Blood Transfus. 2012 Oct 11:1-5.
ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia.
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