Риск выкидыша при использовании глюкокортикоидов

[Melnichenko]

Хотя понятно , что полученные данные не могут быть напрямую эстраполированы на наших фанатов лечения тонуса матки метипредом, тем не менее

Risk of miscarriage among users of corticosteroid hormones: a population-based nested case-control study Full Text
Clinical Epidemiology, 11/01/2013  Evidence Based Medicine Clinical



Bjorn AM, et al. –Целью этого исследования было установление ассоциации между использованием глюкостероидов и риском выкидыша .

•Authors identified prescriptions for corticosteroids before the miscarriage/index date.
•They estimated odds ratios (ORs) for miscarriage and for early (<13 weeks) and late (13–21 weeks) miscarriage adjusting for age, history of diabetes and epilepsy, and nonsteroidal anti–inflammatory drug use.


Results
•They identified 10,974 women with miscarriage and 109,740 controls.
•Prevalence of inhaled corticosteroid use within 60 days before the index date was 1.3% among the cases and 1.0% among the controls (OR = 1.20; 95% confidence interval [CI] 1.01–1.44).
•Prevalence of oral corticosteroid use within 60 days before the index date was 0.3% for both cases and controls (OR = 0.78; 95% CI 0.53–1.15).
•For inhaled and oral corticosteroids, the ORs of early miscarriage were 1.22 (95% CI 1.01–1.49) and 0.81 (95% CI 0.55–1.20), respectively.



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