DHT блокаторы и андрогенетическая алопеция

[agonia]

уважаемый доктор ,очень я интересуюсь миноксидилом,попыталась я прочитать всю вашу дискуссию ,но к сожалению я слабо владею английским,одно могу сказать миноксидил мне помогает ,а у меня как раз андрогенетическая алопеция,пользуюсь я именно кирклындом,мой супруг уже 3 года на нем сидит ,результат отличный вот хочу вас спросить не можете ли вы найти адрес Kirkland? мне очень нужно,пробовала сама,но там всего столько выскакивает,а миноксидильчик мне помог обьективно ,я ведь не истеричка внушаемая,а доктор,заранее благодарю.

[tino]

Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer.

Magerl M, Paus R, Farjo N, Muller-Rover S, Peters EM, Foitzik K, Tobin DJ

Exp Dermatol 2004 Oct;13(10):635-42.
Department of Biomedical Sciences, University of Bradford, Bradford, UK. FAU - Magerl, Markus
PMID: 15447724 [PubMed - indexed for MEDLINE]

Minoxidil induces new hair growth in approximately one-third of patients with androgenetic alopecia after 1 year of treatment. With several conflicting reports in the literature based on small-scale studies, the current study aimed to clarify whether organ culture of human scalp anagen VI hair follicles is a suitable in vitro test system for reproducing, and experimentally dissecting, the recognized in vivo hair-growth-promoting capacity of minoxidil. Hair shaft elongation was studied in terminal anagen VI hair follicles microdissected from the occipital scalp of 36 healthy adults. A total of 2300 hair follicles, approximately 65 per individual, were tested using modifications of a basic organ culture protocol. It is shown here that minoxidil does not significantly increase hair shaft elongation or the duration of anagen VI in ex vivo culture despite several enhancements on the conventional methodology. This disparity to what is seen clinically in minoxidil responders may be explained by the following: (i) use of occipital (rather than frontotemporal or vertex) hair follicles; (ii) use of, already maximally growing, anagen VI hair follicles; (iii) a predominance of hair follicles from minoxidil unresponsive-donors; (iv) use of minoxidil rather than its sulfate metabolite; and/or (v) use of a suboptimal minoxidil dosage. This disparity questions the usefulness of standard human hair follicle organ culture in minoxidil research. Unexpectedly, minoxidil even inhibited hair shaft elongation in the absence of insulin, which may indicate that the actual hair-growth-modulatory effects of minoxidil depend on the concomitant local presence/absence of other growth modulators.



Minoxidil may not work,btw it could inhibit hair growth in the absence of growth-factors like IGF-1 or insulin,VEGF etc.The DHT-Synthesys in the dermal papilla inhibits the expression aof these growth factors.Thats why i think its better to use minoxidil always together whith a 5-alpha-reductase inhibitor,or a topical antiandrogen like fluridil and not alone.

regards Tino