Всё экзотичнее...

[Samitin]

Блумберг ([Ссылки доступны только зарегистрированным пользователям ]):

The U.S. Food and Drug Administration is warning doctors and patients that some widely used diabetes drugs may, in some rare cases, cause a flesh-eating bacterial infection of the genitals.

The condition, known as Fournier’s gangrene, developed in a dozen patients shortly after they began taking the medicines between March 2013 and May 2018, the FDA said. The seven men and five women were all hospitalized and underwent surgery for the condition. One patient died.

More cases may be uncovered once the risk is better understood, the agency said in a statement.

The drugs covered by the warning include Johnson & Johnson’s Invokana, AstraZeneca Plc’s Farxiga and Eli Lilly & Co.’s Jardiance.

Благо, очень большая редкость.

[ELENA_VLAD]

Не нашла - есть ли зависимость между степенью глюкозурии и инфицированием.

[Samitin]

Вряд ли кто-то привязывал количество глюкозы в моче к тяжести последствий на 12 пациентах, тем более, что препарат отменялся при появлении признаков инфекции.
Более примечательно увеличение доли женщин с гангреной Фурнье на глифлозинах, а также увеличение общей частоты случаев инфекции в сравнении с другими видами терапии.

Из [Ссылки доступны только зарегистрированным пользователям ] FDA:

Overall published literature about the occurrence of Fournier’s gangrene for men and women is very limited. Publications report that Fournier’s gangrene occurs in 1.6 out of 100,000 males annually in the U.S., and most frequently occurs in males 50-79 years (3.3 out of 100,000).1-3 In our case series, however, we observed events in both women and men.

In the five years from March 2013 to May 2018, we identified 12 cases of Fournier’s gangrene in patients taking an SGLT2 inhibitor. This number includes only reports submitted to FDA* and found in the medical literature,4-6 so there may be additional cases about which we are unaware. In 2017, an estimated 1.7 million patients received a dispensed prescription for an SGLT2 inhibitor from U.S. outpatient retail pharmacies.7 Although most cases of Fournier’s gangrene have previously been reported in men, our 12 cases included 7 men and 5 women. Fournier’s gangrene developed within several months of the patients starting an SGLT2 inhibitor and the drug was stopped in most cases. All 12 patients were hospitalized and required surgery. Some patients required multiple disfiguring surgeries, some developed complications, and one patient died. In comparison, only six cases of Fournier’s gangrene (all in men) were identified in review of other antidiabetic drug classes over a period of more than 30 years.

Опять же, данные относятся к САСШ с поголовной модой на гигиеническое обрезание. Сейчас будут более активно данные накапливать, но пока частота всё равно мала, хотя осложнение весьма серьёзное.