#256
|
||||
|
||||
Интересная работа от датчан: они опять показали, что и ферритин и железо/ожсс (TS) ассоциируется с выживаемостью, причем как дефицит железа так и его избыток отрицательно влияют на продолж. жизни, оптимальные цифры мало зависят от Ц-реактивного белка:
The ferritin level associated with lowest mortality was 60 µg/L for females and 125 µg/L for males with CRP < 10 mg/L. It was 52 µg/L for females and 118 µg/L for males with CRP ≥ 10 mg/L. The TS level associated with lowest mortality was 33.9% for females and 32.3% for males with CRP < 10 mg/L. It was 28.7% for females and 30.6% for males with CRP ≥ 10 mg/L. --- Scand J Clin Lab Invest. 2022 Oct 11;1-8. Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study
__________________
Искренне, Вадим Валерьевич. |
#257
|
||||
|
||||
еще одна публикация, показывающая, что ферритин менее 50 является ранним маркером дефицита железа, согласно изменениям в крови гепцидина и уровня рецепторов к трансферрину:
ferritin level < 50 ng/mL is the clinical threshold to redefine and consider ferropenia, in order to achieve an early diagnosis and initiate treatment for iron deficiency. --- Threshold Ferritin Concentrations Reflecting Early Iron Deficiency Based on Hepcidin and Soluble Transferrin Receptor Serum Levels in Patients with Absolute Iron Deficiency. Nutrients. 2022 Nov 10;14(22):4739.
__________________
Искренне, Вадим Валерьевич. |
#258
|
||||
|
||||
в/в феринджект детям до 18 лет, подробно обо всем в полном тексте
A retrospective cohort of 144 consecutive patients aged 18 months to<18 years with iron deficiency anemia (IDA) or iron deficiency (ID) without anemia was investigated. All patients had failed oral iron therapy. 100 of 117 (85 %) of patients with complete data achieved the target ferritin level≥30 µg/L after a single FCM dose. Of 77 patients with IDA and complete data, 38 (49%) showed a complete hematological response within 6-12*weeks; a complete or partial response was achieved by 83%. Clinical symptoms improved in 85% of all patients. In 92% of patients (n=133 /144), FCM infusion was uneventful. During the 96-hour follow-up, 5 patients reported potentially related symptoms. No serious adverse events occurred. Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents [Ссылки доступны только зарегистрированным пользователям ]
__________________
Искренне, Вадим Валерьевич. |
#259
|
||||
|
||||
феринджект у беременных с анемией - ответ по гемоглобину через 4 недели после введения:
тяжелая анемия Hb < 70 - повышение на 36 г/л средней тяжести Hb 70 to 99 - повышение на 27.4 г/л лёгкая анемия Hb 100-110 - повышение на 20 г/л риск поб. действия 8.6% Obstet Gynecol Int. 2022 Nov 28;2022:5759740. Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnancy: A Subgroup Analysis of a Multicenter Real-World Study Involving 1191 Pregnant Women [Ссылки доступны только зарегистрированным пользователям ]
__________________
Искренне, Вадим Валерьевич. |
#260
|
||||
|
||||
изменения глико-гемоглобина при различных анемиях в сравнении с контролем у пациентов без диабета:
control group at 5.32% (95% CI = 5.22-5.41) megaloblastic anemia were 5.38% (95% CI = 5.26-5.5) beta thalassemia trait 5.45% (95% CI = 5.21-5.69) iron deficiency anemia at 5.75% (95% CI = 5.68-5.82) sickle cell anemia at 5.83% (95% CI = 5.39-6.28) лечение железом снизило его цифры на 0.3%, но не до цифр контрольной группы HbA1c significantly decreased from 5.75 to 5.44% after treatment in the iron-deficient group --- BMC Endocr Disord. 2023 Jan 28;23(1):24. The effect of different types of anemia on HbA1c levels in non-diabetics
__________________
Искренне, Вадим Валерьевич. |