Макроглобулинемия Вальденстрема и Множ. миелома секретирующая IgM

[Nirsix]

Здраствуйте! Интересует любой материал любого автора по:
1) дифференциальному диагнозу между Макроглобулинемией
Вальденстрема и ММ секретирующей IgM или около этих тем;
2) случаи перехода лимфоплазмоцитарной лимфомы в плазмацитому(костные деструкции, НЕ МЯГКИЕ ткани) или существование двух одновременно.

[Dr.Vad]

по первой теме неплоха недавняя статья (если будет нужда в полной версии - напишите просьбу первому автору)

Am J Hematol. 2010 Nov;85(11):853-5.

IgM multiple myeloma: disease definition, prognosis, and differentiation from Waldenstrom's macroglobulinemia.

Schuster SR, Rajkumar SV, Dispenzieri A, Morice W, Aspitia AM, Ansell S, Kyle R, Mikhael J.

Division of Hematology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
schuster.steven1 @ mayo.edu

IgM multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM) are two distinct hematologic entities with the common finding of an IgM monoclonal gammopathy. Distinguishing these two diagnoses is critical as the approach to therapy is different. A priori, we defined IgM MM as a symptomatic clonal plasma cell proliferative disorder characterized by an IgM monoclonal protein (regardless of size), 10% or more plasma cells on bone marrow biopsy, plus the presence of lytic bone lesions and/or translocation t(11;14). Twenty-one patients met this definition of IgM MM. All 21 patients had lytic bone lesions. Of the 16 evaluated with FISH, 6 (38%) demonstrated t(11;14). Median overall survival was 30 months, which is similar to non-IgM myeloma patients treated during this period and shorter than what would be expected for WM. In this, the largest series of patients with IgM MM, we describe the clinical features and prognosis of patient with IgM MM using a strict definition for the disease. The subset of patients without lytic lesions or t(11;14) but with immunophenotypic features suggestive of MM need further study.