Антикоагулянты

[Муромец]

Здравствуйте!

Нашему институту необходима информация о результатах клинических исследований антикоагулянтов ЦФГ, ЦФГА, Фаглюцид и Глюгицир. Большая просьба, если кто-нибудь располагает информацией о результатах клинических исследований какого-то из этих антикоагулянтов, вышлите по электронной почте или дайте ссылку в Интернет. Буду также очень признателен, если вы сообщите нам организации, которые проводили такие исследования.

[Dr.Vad]

Уважаемый коллега!
Похоже Фаглюцид близок к ЦФГА, а глюгицир - к ЦФГ но без фосфатного буфера, те ЦГ;
не скажу за все названия, особенно отечественные (и произведенные в отечестве), но ЦФГ (CPD) и ЦФГА (CFDA-1/2) сравнивались:

Blood. 1979 Jul;54(1):280-4.
The storage of hard-packed red blood cells in citrate-phosphate-dextrose (CPD) and CPD-adenine (CPDA-1).
Beutler E, West C.
The preservation of red cells "hard packed" to a hematocrit of over 80% from blood collected in citrate-phosphate-dextrose (CPD) or CPD-adenine (CPDA-1) has been investigated. After 21 days of storage, cells that had been collected in CPD solution had consumed most or all of the available glucose and manifested markedly impaired viability after reinfusion into the normal donor. In contrast, red cells prepared from blood collected in CPDA-1, a medium containing supplementary adenine and an increased amount of glucose, maintained higher glucose and ATP levels and, in most instances, manifested satisfactory posttransfusion viability. We emphasize that in addition to providing longer shelf life of stored blood, CPDA-1 provides a better hard-packed red cell concentrate for transfusion at 21 days.

Transfusion. 1983 Nov-Dec;23(6):484-9.
Characterization of biochemical changes occurring during storage of red cells. Comparative studies with CPD and CPDA-1 anticoagulant-preservative solutions.
Moroff G, Dende D.

CPDA-1, containing 0.25 mM adenine (final concentration) and 25 percent more glucose than CPD, has extended the allowable storage time for red cells to 35 days. Studies were conducted to understand better the characteristics of stored CPDA-1 red cells in relation to the properties of stored CPD red cells. Units with hematocrits near 80 percent showed the following: First, ATP and total adenine nucleotide levels of red cells stored with CPDA-1 remained essentially constant during the first 3 weeks of storage after which the levels decreased; with red cells stored with CPD, ATP, and adenine nucleotide, levels were decreased even after 1 week of storage. Second, the pattern of the fall in 2,3-diphosphoglycerate was similar in red cells stored with CPD and CPDA-1. Third, changes in plasma and red cell levels of sodium and potassium, and in plasma ammonia levels, were comparable in CPD and CPDA-1 units; changes in cation levels were most pronounced during the initial 2 weeks of storage. Fourth, hemolysis was much greater in units stored in CPDA-1 for 35 days than in units stored in CPD for 21 days. Fifth, residual glucose concentrations were adequate in units drawn in CPDA-1 and stored for 35 days. We conclude that the changes in the biochemical characteristics of units of red cells stored with CPD and CPDA-1 are similar in most instances with the notable exception of the better maintenance of adenosine triphosphate levels in red cells stored with CPDA-1.

Наверное, ЦФГА/Глюгицир дольше сохраняют эритромассу (правда утверждения "50 дней" слишком оптимистичные, вернее будет 35-42 суток), по сравнению с ЦФГ - 21 день.

J Lab Clin Med. 1983 Jul;102(1):53-62.

Storage of red cell concentrates in CPD-A2 for 42 and 49 days.

Beutler E, West C.

CPD-A2 is a modified CPD blood preservative with adenine, containing 1 1/2 times as much glucose as CPD. Units (450 ml) of blood from 21 normal donors were collected in CPD-A2 in plastic bags and held at room temperature for 8 hr. An 80% red cell concentrate was prepared and this was stored for 42 or 49 days at 4 degrees C, with the containers in either a standing or lying position. The size of the "fragile tail" of osmotically fragile red cells was estimated in 12 samples. The poststorage 24 hr viability of their own stored 51Cr-tagged red cells was documented in 19 of the volunteers. At least 4 months after the original donation, a second unit of blood was collected from eight of the donors to make possible intradonor comparison of the biochemical effects of storage position. After 42 days but not after 49 days of storage, red cells in concentrates stored in the lying position had consumed more glucose and had a higher poststorage pH than did cells stored in the standing position. The poststorage 24 hr viability of red cells stored for 42 days averaged 83.6%, with all units exceeding 70% viability. At 49 days the average viability was 69.1%. Although the average viability of cells stored in the lying position for 42 days was higher than that of concentrates stored standing, the difference was not statistically significant at the 5% level. The plasma hemoglobin level showed a weak correlation with viability of stored cells. Red cell ATP levels were correlated with viability only at 42 days' and not at 49 days' storage. Concentrates of red cell collected in CPD-A2 manifested fully satisfactory viability for 42 days. At 49 days storage the results of viability studies were borderline.

[Муромец]

Dr. Vad, большое спасибо! Вы нас очень выручили