Интересные появляющиеся статьи

[Dr.Anisimova]

Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience
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Conclusions Our study confirms that nail involvement may be overlooked in psoriasis patients. Different psoriatic patterns in the nail affect specific digits more frequently.

Psoriasis common side effect of IBD therapy in women
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Conclusions In this analysis, psoriasiform lesions related to anti-TNF therapy in inflammatory bowel disease occurred most commonly in women. Approximately 41% of those who developed psoriasis while on anti-TNFs responded to topical therapy and were able to continue the drug, while 52% of those treated with an alternate anti-TNF had recurrence of the rash
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Comorbidities significantly impact patients’ preferences for psoriasis treatments
Conclusions
Integrating patients’ preferences into shared decision-making may facilitate treatment adherence and optimize outcomes. Addressing patients’ comorbidities, particularly depression, may be a currently neglected opportunity to improve care.

Differential psoriasis diagnosis required to exclude tinea corporis co-infection
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Bacterial diversity altered in skin of psoriasis patients
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Nail involvement in psoriasis increases risk for subclinical enthesopathy[Ссылки доступны только зарегистрированным пользователям ]
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Conclusion The link between nail disease and contemporaneous subclinical enthesopathy offers a novel anatomical basis for the predictive value of nail psoriasis for PsA evolution.

The Impact of Psoriasis on Pregnancy Outcomes
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Combination therapy seems best for relief of psoriasis: report
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Conclusions* The results demonstrate the need for additional long-term trials with standardized outcome measures to evaluate the efficacy and adverse effects of combination therapies for psoriasis and highlight the possible effects of trial design characteristics on results.

[Dr.Anisimova]

Intensive topical treatment effective for controlling severe pediatric AD
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Conclusion
Intensive inpatient treatment (with wet dressings and topical corticosteroids) was highly effective in controlling severe and recalcitrant atopic dermatitis. Intensive topical treatment, although underused, is an effective first-line approach for patients with severe atopic dermatitis.

Second-Generation H1-Antihistamines in Chronic Urticaria: An Evidence-Based Review
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Topical fluticasone propionate: intervention and maintenance treatment options of atopic dermatitis based on a high therapeutic index
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Topical calcineurin inhibitors in the treatment of atopic dermatitis – an update on safety issues
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Wet dressing therapy in conjunction with topical corticosteroids is effective for rapid control of severe pediatric atopic dermatitis: Experience with 218 patients over 30 years at Mayo Clinic
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A study of the correlation between molluscum contagiosum and atopic dermatitis in children.
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Парацетамол
Maternal exposure to acetaminophen, particulate matter increases childhood eczema risk
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the findings of the study suggest that Paracetamol use by mothers in pregnancy is not an independent risk factor for eczema in children, however, even very small doses of Paracetamol taken in pregnancy may contribute to the occurrence of allergic symptoms in early childhood if there is prenatal co-exposure to higher airborne fine particulate matter.

Dead Sea baths effective treatment for severe atopic dermatitis[Ссылки доступны только зарегистрированным пользователям ]
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Conclusion Dead Sea climatotherapy is a particularly effective treatment method for the sub-population of adults with severe AD. The SCORAD 75 can be useful for defining sub-populations in which treatment is more likely to be successful.

Management of chronic spontaneous urticaria in real life – in accordance with the guidelines? A cross-sectional physician-based survey study
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Conclusion The diagnostic and therapeutic management of csU by private practice physicians does not sufficiently comply with the guidelines. Awareness of the guidelines can lead to improved care.

Hypersensitivity reactions to metallic implants – diagnostic algorithm and suggested patch test series for clinical use
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Patch testing is the gold standard for evaluation of type IV hypersensitivity reactions. Appropriate and extensive patch testing is indicated in patients with implanted metal devices and suspected metal hypersensitivity reactions. Although routine pre-implant patch testing is not recommended, there is a subset of individuals with a prior history of reported cutaneous metal hypersensitivity who should be patch tested prior to device implantation. Use of the tables and patient selection algorithms should make the patient selection for testing and allergens that is necessary for thorough evaluation simple and clear. Management following diagnosis of metal hypersensitivity is controversial. There are no objective criteria for determining which patients should undergo additional surgery, with the unavoidable risks and discomforts involved.
There are two final considerations regarding the approach to potentially metal-allergic patients. First, a positive patch test result (an immunological process) is not necessarily relevant to a clinical disease process (allergic contact dermatitis and symptoms such as joint loosening). Do not make management decisions on the basis of a positive test result alone. Second, there are few prospective data available that meet the diagnostic postulates suggested by Thyssen on which to base decisions in these challenging patients (5). Prospective trials are needed to closely examine these patients and provide evidence for an evidence-based approach.

Case report: allergic contact cheilitis caused by ceresin wax
Ceresin is a mineral wax obtained from ozokerite (1). Its structure is similar to that of paraffin, providing a good level of flexibility, adhesiveness, and water resistance. When chlorinated, ceresin is a useful varnish product (1), and it is thus commonly used in floor waxes, textiles, and rubber compounds (2). Although rare, there are reports of occupational dermatoses, particularly among workers using ceresin-containing varnishes (1).
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Occupational contact urticaria caused by polyvinylchloride gloves
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Allergy to natural rubber latex (NRL) gloves in healthcare workers is well recognized, and usually presents as immunological contact urticaria and sometimes anaphylaxis. Latex gloves can also cause allergic contact dermatitis, mostly because of rubber accelerators. As latex sensitivity is well known in healthcare settings, synthetic latex-free gloves are widely used. The most popular latex-free gloves are made of nitrile, polyvinylchloride (PVC), neoprene, or polyethylene. Only a few cases of contact urticaria caused by synthetic rubber or plastic materials have been reported. We describe a case of occupational contact urticaria caused by PVC gloves.

Allergic contact dermatitis caused by a skin-lightening agent, 5,5?-dipropylbiphenyl-2,2?-diol
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Many skin-lightening agents are currently available, including kojic acid, arbutin, hydroquinone, and 5,5?-dipropylbiphenyl-2,2?-diol (Fig. 1); the last of these is a relatively new skin-lightening agent that has been used in Japanese cosmetics since 2006. 5,5?-Dipropylbiphenyl-2,2?-diol is a biphenyl derivative, and downregulates melanin synthesis by inhibiting tyrosinase maturation, leading to accelerated tyrosinase degradation (1). Here, we report a case of allergic contact dermatitis caused by 5,5?-dipropylbiphenyl-2,2?-diol.

Profilaggrin, Dry Skin, and Atopic Dermatitis Risk: Size Matters
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FLG gene, which encodes profilaggrin, are known to be a major risk factor for atopic dermatitis as well as other atopic diseases and systemic allergies. New research, however, shows that intragenic copy number variation within FLG also represents an independent risk factor for atopic dermatitis. The new findings indicate that upregulating FLG protein levels by 5–10% may have clinical utility in improving the management of many patients with dry skin and atopy.

Patch Testing With a Large Series of Metal Allergens
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Conclusion: Many metals not in the standard series were associated with allergic patch-test reactions. The many questions raised by these findings, concerning patch testing with individual metals, will be the subject of future studies.

Efficacy and safety of topical halometasone in eczematous dermatoses in Indian population: An open label, noncomparative study
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Сикортен (Sicorten)
Крем 0,05% по 30 г в тубе, мазь 0,05% по 30 г в тубе
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[Dr.Anisimova]

Evidence-Based Dermatology: Everyone's Business
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- межпальцевая эритразма(лампа Вуда, микроскопия)
The prevalence of interdigital erythrasma in southern region of Turkey
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Conclusion Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Wood’s lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Wood’s lamp result, may be a useful method.

Cutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera
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Oral lichen planus
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Face and scalp cosmetic surgery may increase lichen planopilaris risk
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- рубцы
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: First report of a potential combination therapy
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Conclusion
The cytotoxic effect of PDT on keloid fibroblasts can be enhanced significantly with addition of DW stimulation, indicating for the first time the utility of this potential combinational therapy.

Fractional CO2 laser can reduce scarring after surgery
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A Randomized Split-Scar Study of Intraoperative Treatment of Surgical Wound Edges to Minimize Scarring

Hidradenitis Suppurativa
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Conclusion* Our study demonstrates for the first time, to our knowledge, that a deficiency of the main innate immunity markers in typical HS sites may explain the development of chronic inflammatory nodules in this disease.

Oxalosis Involving the Skin
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Conclusions* This case highlights the variability of clinical presentations in primary hyperoxaluria and that the disease can be diagnosed in adulthood. In addition, this case demonstrates that hyperoxaluria should be included in the differential diagnosis of calciphylaxis and nephrogenic systemic fibrosis.

Journal of the American Academy of Dermatology
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Pruritic lichenoid lesions on the vulva of an 11-year-old girl
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Progressive nodular histiocytosis: a rare type of xanthogranuloma
Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis
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Systemic isotretinoin with topical tretinoin cream in the treatment of multiple warty dyskeratomas
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- еще одно издание от Elsevier(полнотекстовые статьи)
- о журнале:
"The Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating medical science knowledge to improve global health. Articles on clinical, laboratory and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, case reports, short communications, and letters to the editor are accepted. The journal is published every 3 months, with a total of 4 issues a year."
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Последние статьи:
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Pruritic lichenoid lesions on the vulva of an 11-year-old girl
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Progressive nodular histiocytosis: a rare type of xanthogranuloma
Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis
[Ссылки доступны только зарегистрированным пользователям ]
Systemic isotretinoin with topical tretinoin cream in the treatment of multiple warty dyskeratomas
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Three-Year Outcomes of the Surgery for Trichiasis, Antibiotics to Prevent Recurrence Trial
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Conclusion* Trichiasis recurrence rates in the STAR trial remained low for up to 3 years following surgery. The protective effect of a single dose of azithromycin was less than at 1 year and, although not statistically significant, was still suggestive up to 3 years following trichiasis surgery.
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- доступно через сайнс дайрект полнотекстовые статьи

A rare case of idiopathic neutrophilic dermatosis of the hands
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ree access to most cited articles!!!
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"Free Full Text Articles": Where to search for them?
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In vivo antinuclear antibodies of the skin
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Asymptomatic nodule over the shin
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Neurocutaneous spectrum of multiple endocrine neoplasia-1
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Unilateral linear punctate palmoplantar keratoderma
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- кожные инвазии:
Dermatologic infestations
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Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani
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[Dr.Anisimova]

Как раз последние интересные полнотекстовые статьи этого журнала:
Early-onset childhood sarcoidosis: a case report
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Mimicking each other: psoriasis with tinea incognito
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Serum levels of minerals and vitamins in two categories of female alopecia subjects using hair relaxer
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Conclusion
This is probably an indication that early exposure may confer some forms of protection even in zinc-deficient individuals. Moreover, an assessment of serum zinc level in users of hair relaxer may be encouraged even before initial contact with this agent, such that women at risk could be advised to take zinc supplements.

Corticosteroid-induced Dercum’s disease
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Dercum’s disease is a rare disorder characterized by diffuse or localized painful fatty deposits, occurring primarily in postmenopausal, obese women of middle age.

Peculiar brownish eruption and superficial lymphadenopathy in a middle-aged man
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Cutaneous plasmacytosis (CP).

Large cell acanthoma manifesting as multiple white papules on extremities
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Dyschromatosis universalis hereditaria: a familial case with ultrastructural skin investigation
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Concurrent pyoderma gangrenosum and subcorneal pustular dermatosis in a patient with monoclonal IgA/λ gammopathy
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Palisaded neutrophilic and granulomatous dermatitis associated with the initiation of etanercept in rheumatoid arthritis: a case report
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[Dr.Vad]

Although not common, chronic urticaria due to nickel allergy, is a challenging task for the dermatologist. Dietary nickel acts as a major precipitating factor in this condition. One of the accepted methods of treating such urticaria is a low nickel diet (LND). In this method, the patient is given a list of dietary items that contain low amounts of nickel and the patient is instructed to stick to these items. The purpose is to reduce the uptake of nickel by the body from the diet and thereby, to minimize the risk for endogenous activation of immunocompetent cells in nickel-sensitive individuals.

Usually retention of dietary nickel by the human body is low; it is estimated to be 3-6% of the total nickel absorbed. It is seen that absorption of nickel in the human body can be enhanced by iron deficiency [1] and thus, an individual with iron deficiency anemia (IDA) tends to retain more nickel from the diet. This is due to the upregulation of divalent metal transporter (DMT) protein in intestinal the mucosa of the individual with IDA. DMT protein is present on the luminal surfaces of enterocytes of the intestinal epithelium, whose function is to transport iron (Fe ++ ) from the diet into the enterocyte of the intestinal mucosa. In the absence or paucity of iron in the diet, the DMT protein tends to immediately bind and transport other available divalent cation(s), including nickel across the membrane. This is important for those suffering from nickel allergy because nickel is a ubiquitous trace element and is present in most of the human foods. In other words, individuals with IDA are at a higher risk to accumulate nickel in their body. Conversely, it has also been found that adequate iron intake and status can limit nickel absorption due to the downregulation of DMT protein on the luminal surfaces of enterocytes. [2],[3]

It is a fact that IDA is widely prevalent in India. The National Family Health Survey 3 (2005-2006) estimates reveal the prevalence of anemia to be 70-80% in children, 70% in pregnant women, and 24% in adult males. The report also estimates that at least 65-75% of adolescent girls in India are anemic, the most common cause for IDA is a diet that is poor in iron.

A small study was undertaken to observe the benefits of the addition of oral iron to an LND in the treatment of chronic urticaria due to nickel sensitivity in women with iron deficiency anemia (IDA). The study included five female patients (age group: 18-25 years) with chronic urticaria due to nickel allergy (confirmed by patch testing) and mild to moderate IDA. A oral challenge was done with nickel sulfate to confirm the diagnosis of nickel allergy. Patients were thoroughly investigated to rule out the problems of bleeding gums, hematemesis and melaena, bleeding per anum, menorrhagia, hematuria, worm infestation, and abnormal blood picture. None of the patients reported the use of any surgical prosthesis. Both verbal and written consent was taken from all the patients. Pregnant or lactating patients were not included in this study.

Patients were divided into two groups: patients in the study group (n = 3) were advised a LND along with oral iron (50 mg of elemental iron thrice daily) for a period of six weeks; patients in the control group (n = 2) were advised a LND alone for the same duration. All were advised to avoid contact with articles that might contain nickel during this period. Clinical improvement was evaluated with the help of urticaria activity scores (UAS) at weekly intervals. Patients were asked take oral antihistaminics on sos basis only.

The results observed in the study group were interesting. The severity of the urticaria reflected in the UAS, was reduced significantly in all three cases by the end of two weeks. Two patients were free from urticaria by the end of the 3rd week and the remaining one patient was free from urticaria by the end of the 4th week. They no longer needed to use oral antihistaminic agents. All of them were free from urticaria for the rest of the trial period. Partial reduction was observed in the severity of urticarial activity by the end of two weeks in the control group. A further reduction in the severity of urticaria was noted in these patients by the end of the 4th week. However, no further improvements were observed in the remaining two weeks. Patients were able to reduce the frequency of use of oral antihistaminic agents.

The author concluded that a combination of an LND and oral iron can bring about a faster reduction in the severity of urticarial activity in nickel-sensitive individuals with IDA. However, the present study is a small clinic-based study. A further multicentric study comprising of large number of patients with longer follow-up will be more informative.

[Dr.Vad]

Zinc and skin: A brief summary
Dermatol Online J. 2012 Mar 15;18(3):1.
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[FBN]

British Association of Dermatologists' Guidelines for the Management of Alopecia Areata 2012
A.G. Messenger; J. McKillop; P. Farrant; A.J. McDonagh; M. Sladden
The British Journal of Dermatology. 2012;166(5):916-926.
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С уважением, Федий Богдан Николаевич.

[Dr.Vad]

Публикация из Японии об опыте применения препарата цинка (33 мг в день) в течение 4-12 мес. у 5 пациентов (2 пациента с хеликобактерным гастритом) в данным видом алопеции и одновременным дефицитом цинка, установленным как его снижение менее 80 мкг/дл (менее 0.8 мг/л) (менее 1.22 мкМ/л). Прекращение/снижение выпадения волос сопровождалось повышением концентрации цинка в крови:

Dermatol Ther. 2012 Mar;25(2):210-3.
Oral zinc therapy for zinc deficiency-related telogen effluvium.
Karashima T, Tsuruta D, Hamada T, Ono F, Ishii N, Abe T, Ohyama B, Nakama T, Dainichi T, Hashimoto T.
Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.

Zinc is crucial for maintaining human body homeostasis and is one of the major components of hormones, signal molecules, and enzymes. Zinc deficiency is caused by insufficient uptake of zinc from food, or caused by malabsorption syndromes, increased gastrointestinal and urinary losses, and administration of various medications. In order to test whether oral zinc administration can successfully improve zinc deficiency-related alopecia, we treated five patients with zinc deficiency-related telogen effluvium with oral zinc administration in the form of polaprezinc. In all patients, hair loss was cured or improved. The administration of zinc for zinc deficiency-related alopecia may recover appropriate activities of metalloenzymes, hedgehog signaling, and immunomodulation, all of which are required for normal control of hair growth cycle.

[FBN]

Статья: Практическое руководство по дерматологическому употреблению лекарственных препаратов во время беременности.
A Practical Guide to Dermatological Drug Use in Pregnancy.
C. Zip, MD, FRCPC
Ссылка: [Ссылки доступны только зарегистрированным пользователям ]

С уважением, Федий Богдан Николаевич.

[Dr.Vad]

J Korean Med Sci. 2013 Jun;28(6):934-8.
Iron plays a certain role in patterned hair loss.

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[Dr.Anisimova]

- для трихологов и не только(большая часть номера ijdvl посвящена трихологии), доступен формат HTML Full text:
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Alopecia areata: An updatе
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- журнал трихологии
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A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study
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[Dr.Anisimova]

Поясню, что статья "A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study" является пилотным исследованием, но тем не менее, может быть полезна и для пациентов (по применению дермароллера с миноксидилом )
Conclusion: Dermaroller along with Minoxidil treated group was statistically superior to Minoxidil treated group in promoting hair growth in men with AGA for all 3 primary efficacy measures of hair growth. Microneedling is a safe and a promising tool in hair stimulation and also is useful to treat hair loss refractory to Minoxidil therapy.

[Dr.Anisimova]

- "официально" уже широко распространилось выделение формы ГА сизафио, (форма, обратная офиазису)
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- интересная статья с "кольцевидной" формой ГА:
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- трихотилломания, в т.ч. семейный случай(3 поколения) :
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- обычно при ГА, при псориазе, КПЛ дистрофии ногтей очень тяжелые, как вариант лечения: тяжелый онихолизис при ГА лечили системным применением триамцинолона (triamcinolone acetonide 0.5 mg/kg/month, for 3 months);
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- диф. диагноз разных видов алопеций:
Alopecia: evaluation and treatment
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Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata part I
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Part II
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[Dr.Anisimova]

сизафио

- в РФ прижился термин "сисафио" как "новая" форма ГА
- по трихоскопии неплохая статья, с алгоритмом:
"Trichoscopy in alopecias: Diagnosis simplified"
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A randomized placebo-controlled double-blind pilot study of methotrexate in the treatment of H1 antihistamine-resistant chronic spontaneous urticaria
Drug advertisements in two dermatology journals: A critical comparison of IJDVL and JAAD
Treatment of multifocal epithelial hyperplasia with imiquimod
Disseminated molluscum contagiosum in a patient on methotrexate therapy for psoriasis
Effects of low-level light therapy on facial corticosteroid addiction dermatitis: A retrospective analysis of 170 Asian patients
и др. в [Ссылки доступны только зарегистрированным пользователям ]

[Dr.Anisimova]

- виагра и риск меланомы
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- по формам розацеа:
Study finds evidence for rosacea subtype progression
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"The four rosacea subtypes, erythematotelangiectatic (subtype 1), papulopustular (subtype 2), phymatous (subtype 3), and ocular (subtype 4), have been classified based on primary and secondary clinical features."
"subtype 3 and 4 were more highly associated with subtype 2 than with subtype 1."
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- профилактика рака кожи-прежде всего защита любыми способами от УФ
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Advances in psoriasis treatment
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Group issues guidelines for treating pediatric acne
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Mesotherapy Approach Shown Effective for Pretibial Myxedema
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-подчеркну: как способ введения стероидных препаратов(дексаметазон)
No FDA Okay Yet for Topical Onychomycosis Drug(efinaconazole)
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