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#1
17.11.2009, 17:03
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Èíòåðåñíûå ïîÿâëÿþùèåñÿ ñòàòüè
Long-term efficacy of a single course of infliximab in hidradenitis suppurativa
B. H. Thiers, MD; Courtesy of Eclips Consult ([Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]) Summary Abstract Background: Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by abscess formation, predominantly in the axillae and groins. The disease is difficult to treat and has a severe impact on quality of life. Recently, several case reports have been published describing successful treatment of hidradenitis suppurativa with infliximab and other tumour necrosis factor α inhibitors. Objectives: To evaluate the long-term efficacy of a single course of infliximab. Methods: Ten patients with severe, recalcitrant hidradenitis were treated with infliximab (three infusions of 5mgkg−1 at weeks 0, 2 and 6) and followed up for at least 1 year. The disease activity was measured using laboratory parameters and a recently developed acne score. The patients rated the efficacy of infliximab on a 10-point scale at regular intervals. Quality of life was measured before and after treatment using the Dermatology Quality of Life Index (DQLI). Results: All patients improved within 2–6 weeks. The average acne score diminished from 164±50 (mean±SD) before treatment to 89±49 after 1 year (P=0·002). The mean CRP (C-reactive protein) was reduced from 31·7mgmL−1 to 5·5mgmL−1 after 1 month (P=0·015). Patients judged the efficacy with a score of 7·9. The mean DQLI was reduced from 18·4±7·9 before treatment to 9·3±9·1 after 1 year (P=0·007). In three patients long-lasting improvement was observed, with no recurrence of lesions in a 2-year follow-up period. The other patients showed recurrence of lesions after 8·5 months (range 4·3–13·4 months). Conclusions: Infliximab is an effective treatment in severe hidradenitis suppurativa, leading to reduction of symptoms for a prolonged period. Commentary by B.H. Thiers, MD Posted Date: 11 Jun 2009 Evidence Ranking: B Hidradenitis suppurativa is a debilitating chronic inflammatory condition of apocrine glands that is highly refractory to treatment. Although some physicians believe it may be related to acne (hence its alternate designation, acne ectopica or acne inversa), the condition responds poorly to treatments used for acne, and even isotretinoin is often ineffective, despite the use of doses higher than one would typically use for treating acne vulgaris. Nonspecific antiinflammatory therapy, including systemic corticosteroids, is useful for short-term control, although long-term administration in a chronic disease such as this is fraught with unacceptable complications. The hypothesis that the proinflammatory cytokine, TNF-α, may be involved in the pathogenesis of hidradenitis has led to numerous case reports of the use of TNF-α inhibitors as a possible treatment. These reports have yielded mixed results. In the study by Mekkes and Bos, a single course of 3 infusions of the TNF-α inhibitor, infliximab, led to short-term improvement in all 10 patients, although 7 relapsed an average of 8.5 months after therapy. A previous study by Fardet et al included 7 patients with hidradenitis who were treated with 3-4 infusions of infliximab.[1] Again, most improved in the short-term, but most relapsed later. In both of these studies, adverse drug reactions were seen in a significant minority of patients. Taken together, the data appear to suggest that TNF-α inhibitors, specifically infliximab, may have some short-term benefit for treating hidradenitis, but maintenance infusions will be necessary to maintain improvement. References 1. Mekkes JR, Bos JD, et al: Long-term efficacy of a single course of infliximab in hidradenitis suppurativa. Br J Dermatol 2008; 158:370-374. 
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#2
29.12.2009, 01:02
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Íåìíîãî íå â òåìó, íî íå çíàþ, êóäà åùå ýòó èíôîðìàöèþ ìîæíî ïîìåñòèòü.
Íà ñàéòå Àìåðèêàíñòêîé àêàäåìèè äåðìàòîëîãèè ìîæíî ñêà÷àòü íåñêîëüêî ðóêîâîäñòâ ïî ëå÷åíèþ íåêîòîðûõ àêòóàëüíûõ êîæíûõ çàáîëåâàíèé (àêíå, àòîïè÷åñêîãî äåðìàòèòà, ïñîðèàçà è ïñîðèàòè÷åñêîãî àðòðèòà): [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#3
23.02.2010, 20:44
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Ìåñòíîå ëå÷åíèå ìåëàçìû (îáçîð)
ïðèìåíåíèå äîêàçàííûõ è ýêñïåðèìåíòàëüíûõ ñðåäñòâ è èõ êîìáèíàöèé â íåäàâíåì îáçîðå
TOPICAL TREATMENT OF MELASMA Indian J Dermatol. 2009 Oct–Dec; 54(4): 303–309. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#5
26.02.2010, 03:03
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- íåíàâÿç÷èâàÿ ñòàòüÿ ïî þâåíèëüíîìó ëàäîííî-ïîäîøâåííîìó äåðìàòîçó
[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - åùå ïîïàäàëàñü ñòàòüÿ î âîçìîæíîé ñâÿçè ñ ÀÄ/àòîïèåé èëè êàê âîçìîæíàÿ ôîðìà àòîïèè [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] "Palmar and plantar dermatitis.— When 2452 newly hired hospital workers were studied, the incidence of the development of hand eczema was three times higher in those who were atopic.[111] In addition, hand eczema has been noted to occur in 70% of children with AD.[112] Atopy has been reported to occur in up to 57% of patients with juvenile palmar-plantar dermatosis.[113] Eczema on the palms and soles presents as a glistening erythema with varying degrees of scaling and fissuring. Lichenification results from the constant rubbing of the xerotic palmar and plantar skin. The dorsum of the hands may or may not be similarly involved. The non-weight-bearing areas of the soles and interdigital spaces are spared. Sparing of the interidigital spaces should defer consideration of a possible dermatophytic infection. The condition runs a chronically relapsing course with worsening in winter, but persistent lesions are noted in approximately 40% of patients.[114]" [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Àëüòåðíàòèâà â ëå÷åíèè óñòîé÷èâîé èäèîïàòè÷åñêîé õðîíè÷åñêîé êðàïèâíèöû(äàïñîí èëè êîëõèöèí) : "Successfully treating patients with resistant chronic idiopathic urticaria (CIU) frequently requires augmenting antihistamine therapy with dapsone or colchicine, an expert says." - ðåòèíîèäû àíòè-age(êðîìå ãëóáîêèõ ìîðùèí) è ïðîôèëàêòèêà ôîòîñòàðåíèÿ(ñòàòüÿ-äèñêóññèÿ) Topical retinoid treatments effective for brown spots, fine wrinkles [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - âîçìîæíûå ïðè÷èíû ëèíåéíîé ïèãìåíòàöèè(õèìèîòåðàïèÿ, áëåîìèöèí) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - âîçìîæíûé òðèããåðû(÷åñîòêà) áóëë¸çíîãî ïåìôèãîèäà: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - äîîïåðàöèîííàÿ îáðàáîòêà õëîðãåêñèäèíîì ëó÷øå, ÷åì éîäîì: "Conclusions Preoperative cleansing of the patient's skin with chlorhexidine–alcohol is superior to cleansing with povidone–iodine for preventing surgical-site infection after clean-contaminated surgery. (ClinicalTrials.gov number, NCT00290290 [ClinicalTrials.gov] .)" Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Wound Infections [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - ïðåäëàãàåòñÿ çàìåíà: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - îá àññîöèàöèè âíóòðåííèõ áîëåçíåé ñ êîæíûìè ñèìïòîìàìè [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - ó íåâàêöèíèðîâàííûõ äåòåé áîëåå âûñîêèé ðèñê âåòðÿíêè(ïî÷òè â 9 ðàç), ÷åì ó âàêöèíèðîâàííûõ Conclusions Children of parents who refuse varicella immunizations are at high risk of varicella infection relative to vaccinated children. These results will be helpful to health care providers and parents when making decisions about immunizing children. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - î, àêòóàëüíî, îáñóæäàþòñÿ äåðìàòîëîãè÷åñêèå ïðîáëåìû ãèíåêîëîãèè(ìíîãî ïàöèåíòîê ñ ñèìïòîìàìè áåç âûÿñíåííîé ïðè÷èíû-çóä, ææåíèå-â ðàçäåëå ãèíåêîëîãèè) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - î "âûñîêîì" è íàì íåäîñòóïíîì â ëå÷åíèè ïñîðèàçà(ñðàâíåíèå ïðåïàðàòîâ) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] "Conclusions The efficacy of ustekinumab at a dose of 45 or 90 mg was superior to that of high-dose etanercept over a 12-week period in patients with psoriasis. (ClinicalTrials.gov number, NCT00454584 [ClinicalTrials.gov] .) " - õèìèîïðîôèëàêòèêà áàçàëüíî-êëåòî÷íîé êàðöèíîìû ñ ÍÏÂÑ ó ãåíåòè÷. ïðåäðàñïîëîæåííûõ(PTCH1+/−) ëþäåé è ìûøåé [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - èññå÷åíèå âèøíåâûõ àíãèîì: Arch Dermatol. 2010;146(1):33-37. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] "Conclusions Cherry angiomata can be effectively treated with electrodesiccation and with laser. Laser, especially PDL, may minimize the likelihood of treatment-associated textural change. " - ðåäêèé KID-ñèíäðîì(Keratitis, ichthyosis, and deafness) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - êîñìåòè÷åñêèå ñîñòàâëÿþùèå: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] ÷åãî ñòîèò èçáåãàòü: " Acne — Avoid mineral oil, beeswax, jojoba oil, coconut oil, palmitates. - Dry skin — Avoid certain surfactants, such as sodium lauryl sulfate, sodium laureth sulfate, soaps with sodium tallowate, witch hazel and salicylic acid. - Sensitive skin — Avoid the same surfactants listed for those with dry skin. Some alpha hydroxy acids, such as glycolic and lactic acids, should also be avoided. " - äåòàëè ëå÷åíèÿ àêíå ó æåíùèí: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#7
02.03.2010, 01:52
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Äåðìàòîëîãèÿ íîâîðîæäåííîãî: ñûïü è ðîäèìûå ïÿòíà
Newborn skin: Part I. Common rashes. O'Connor NR, McLaughlin MR, Ham P. Am Fam Physician. 2008 Jan 1;77(1):47-52. Review. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] --- Newborn skin: Part II. Birthmarks. McLaughlin MR, O'Connor NR, Ham P. Am Fam Physician. 2008 Jan 1;77(1):56-60. Review. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#8
12.04.2010, 22:30
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Nail Abnormalities: Clues to Systemic Disease.
Am Fam Physician. 2004 Mar 15;69(6):1417-24 [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#9
14.04.2010, 18:53
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Âûïàäåíèå ðåñíèö - ìàäàðîç (Madarosis):
Indian J Dermatol Venereol Leprol. 2008 Jan-Feb;74(1):74-6. Madarosis: a dermatological marker. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#10
27.05.2010, 08:42
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- îáñóæäåíèå ðåäêîãî äåðìàòîçà (áîëåçíü Ãóæåðî – Êàðòî, ñëèâàþùèéñÿ è ñåò÷àòûé ïàïèëëîìàòîç); èíòåðåñåí äèô. äèàãíîç ñ áîëåå ÷àñòî âñòðå÷àþùèìèñÿ äåðìàòîëîãó ïðîáëåìàìè(îòðóáåâèäíûé ëèøàé)
Confluent and reticulated papillomatosis(CARP) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - î íåì â emedicine: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Confluent and reticulated papillomatosis: favourable response to low-dose isotretinoin [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - èíòåðåñíûé íåêëàññè÷åñêèé âàðèàíò Ò-êëåòî÷íîé ëèìôîìû êîæè, ïåðâè÷íî-îïóõîëåâàÿ ôîðìà â áëîãå óâàæàåìîãî êîëëåãè Ñåðãååâà Þ.Â. Ò – êëåòî÷íàÿ ëèìôîìà êîæè: «îáåçãëàâëåííûé ãðèáîâèäíûé ìèêîç». [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - òîïè÷åñêîå ïðèìåíåíèå èìèêâèìîäà ïîëó÷èëî îäîáðåíèå FDA äëÿ ëå÷åíèÿ àêòèíè÷åñêîãî êåðàòîçà: Zyclara topical cream (imiquimod 3.75 percent) has been approved by the U.S. Food and Drug Administration to treat actinic keratoses (AKs), a precancerous condition that's commonly found on skin frequently exposed to the sun. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#11
11.09.2010, 09:33
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èç ïîñëåäíèõ íîâîñòåé
- ïîÿâèëèñü áîëåå çíà÷èìûå äàííûå ïî àññîöèàöèè äåìîäåêñà è ïàòîëîãèè êîæè
[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Retrospective Analysis of the Association Between Demodex Infestation and Rosacea Arch Dermatol. 2010;146(8):896-902. doi:10.1001/archdermatol.2010.196 Conclusions: A significant association exists between Demodex infestation and the development of rosacea. Demodex infestation is a vital risk factor for rosacea according to the time-to-event relationship, and the degree of infestation played a more important role than did the mite infestation rate in the development of rosacea. Aggravating factors for melasma: a prospective study in 197 Tunisian patients [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] (ïîñëå ðåãèñòðàöèè äîñòóïåí ïîëíûé òåêñò) Our findings confirm that among women with melasma, the most severe forms of disease commonly appear in women with dark phototypes, those exposed to oral contraceptives and those who have been particularly exposed to the sun during their lives. These severe forms of melasma, which seem to appear more frequently when the disease appears before the age of thirty, generally lead to severe deterioration in quality of life. The study of melasma in this type of population is of major importance because of aesthetic damage in dark-phototype patients, the lack of efficacy of current treatments, non-compliance with photo-protection recommendations and the challenge represented by treatment. Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Risk Factors for Single and Multiple Basal Cell Carcinomas[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusion* Patients who are relatively young at their first BCC diagnosis, those with red hair, those with higher socioeconomic status, and/or those with a BCC lesion on their upper extremities have a higher risk of developing multiple lesions and require closer follow-up over time. - êîððåëÿöèÿ ìåæäó óðîâíåì ïðîëàêòèíà è êëèí.ïðîÿâëåíèÿìè ïñîðèàçà: Serum prolactin levels in psoriasis and correlation with cutaneous disease activity [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions. These results indicate that serum PRL levels may serve as a biological marker of psoriatic disease activity. Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Background Recessive dystrophic epidermolysis bullosa is an incurable, often fatal mucocutaneous blistering disease caused by mutations in COL7A1, the gene encoding type VII collagen (C7). On the basis of preclinical data showing biochemical correction and prolonged survival in col7 ?/? mice, we hypothesized that allogeneic marrow contains stem cells capable of ameliorating the manifestations of recessive dystrophic epidermolysis bullosa in humans. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - ïèâî/ðèñê ïñîðèàçà ó æåíùèí [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Alcohol Intake and Risk of Incident Psoriasis in US WomenConclusions: Nonlight beer intake is associated with an increased risk of developing psoriasis among women. Other alcoholic beverages did not increase the risk of psoriasis in this study. - êîíòàêòíûé äåðìàòèò íà òóàëåòíóþ áóìàãó The Hazards of Moist Toilet Paper [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusion This study highlights that the MCI/MI in moist toilet paper can be a cause of perianal and perineal allergic contact dermatitis. Neonatal dermatological emergencies [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Journal allows access to PDF only to subscribers and users from INDIA. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] -ïåäèàòðèÿ... - íåò êàêîé-ëèáî êîððåëÿöèè: Serum vitamin B12, folate, ferritin and iron levels in Turkish patients with vitiligo [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Acyclovir versus valacyclovir [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Prescribing and dispensing of isotretinoin: A survey [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Lack of association between extramammary Paget's disease and human papillomavirus infection [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - êóðåíèå/ðèñê ãåíèòàëüíûõ áîðîäàâîê: Association between smoking and genital warts: longitudinal analysis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions: Smokers experienced a moderately increased risk of being diagnosed with genital warts. This finding could be explained by the immunosuppressive effects of nicotine, or by confounding not accounted for in the adjusted model. Differential association of ureaplasma species with non-gonococcal urethritis in heterosexual men [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions Unlike U parvum, U urealyticum was associated with urethritis. The strong effect in younger white men and high rates in controls may suggest variability in virulence among U urealyticum strains or in host innate or acquired immunity. Minocycline in Acne Vulgaris: Benefits and Risks [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Considering the aspects of efficacy, its adverse effect profile, resistance, price, and alternatives, minocycline is no longer considered the first-line antibacterial in the treatment of acne. - äîñòóïíî ïîñëå ðåãèñòðàöèè: Treatment of Atopic Dermatitis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Genital Herpes: 21st Century Update [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] A Comparative Study of Dyslipidaemia in Men and Woman with Androgenic Alopecia Female patients with androgenic alopecia showed significant higher triglycerides values (123.8 vs 89.43 mg/dl, p?=?0.006), total cholesterol values (196.1 vs 182.3 mg/dl, p?=?0.014), LDL-C values (114.1 vs 98.8 mg/dl, p?=?0.0006) and lower HDL-C values (56.8 vs 67.7 mg/dl, p Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusion The determination of metabolic syndrome and ultrasound study of the carotid arteries may be useful screening methods to detect risk of developing cardiovascular disease in male and female patients with early-onset AGA and signal a potential opportunity for early preventive treatment. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Original Article: Quantitative detection of melanoma-associated antigens by multimarker real-time RT-PCR for molecular staging: results of a 5*years study Conclusions: Statistically significant tumor marker elevation during the first 2*years after the surgical treatment correlates with a worse prognosis of patients. In contrast, the group showing negative real-time RT-PCR results in 24*months serial blood testing was associated with prolonged 5-year disease-specific survival. Therefore, quantitative detection of melanoma-specific molecular markers in the presented setting represents a useful tool for selecting patients in a higher risk of disease recurrence. The Effect of Narrowband UV-B Treatment for Psoriasis on Vitamin D Status During Wintertime in Ireland [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions* Narrowband UV-B effectively increases serum 25(OH)D level while clearing psoriasis. Up to 75% of Irish patients with psoriasis were shown to be vitamin D insufficient during wintertime.
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#12
11.09.2010, 09:48
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- ïñèõîäåðìàòîëîãèÿ(ðèñê ïñèõè÷åñêèõ èçìåíåíèé ó ïàöèåíòîâ ñ ïñîðèàçîì)
The Risk of Depression, Anxiety, and Suicidality in Patients With Psoriasis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions* Patients with psoriasis have an increased risk of depression, anxiety, and suicidality. We estimate that in the United Kingdom, in excess of 10*400 diagnoses of depression, 7100 diagnoses of anxiety, and 350 diagnoses of suicidality are attributable to psoriasis annually. It is important for clinicians to evaluate patients with psoriasis for these conditions to improve outcomes. Future investigation should determine the mechanisms by which psoriasis is associated with psychiatric outcomes as well as approaches for prevention. Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusion Genetic factors, early allergen sensitization, and having worked in a high-risk job seem to be more important for disease development in late adolescence than other early-life exposures. -äîñòóïåí àï-äýéò ãàäëàéíà ïî ìåëàíîìå: Revised U.K. Guidelines for the Management of Cutaneous Melanoma 2010 [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Prevention of Melanoma A new mole appearing after the onset of puberty which is changing in shape, colour or size A long-standing mole which is changing in shape, colour or size Any mole which has three or more colours or has lost its symmetry A mole which is itching or bleeding Any new persistent skin lesion especially if growing, if pigmented or vascular in appearance, and if the diagnosis is not clear A new pigmented line in a nail especially where there is associated damage to the nail A lesion growing under a nail Multiple elastomas in a 6-month-old child [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Mucocutaneous features of hand, foot, and mouth disease: A reappraisal from an outbreak in the city of Kolkata [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - ïñèõîäåðìàòîëîãèÿ ïîêà îñòàåòñÿ íîâûì è íåèçâåñòíûì íàïðàâëåíèåì äëÿ äåðìàòîëîãîâ äàæå â US Psychodermatology awareness among dermatologists: Results of a mail survey [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] A U.S. mail survey investigated the level of training in and awareness of psychocutaneous disorders (PD) among 102 dermatologists. Only 18% of respondents reported a clear understanding of psychodermatology and only 42% reported being very comfortable in diagnosis or treatment of such disorders. The most common PD disorders were reported as acne, atopic dermatitis and psoriasis. Delusions of parasitosis (41%), neurotic excoriation (24%) and trichotillomania (17%) were commonly reported. When asked whether they would be interested in a PD continuing medical education event, only 39% responded positively (Jafferany, M. et al. Int J Dermatol 2010, 49: 784). - êîñìåòîëîãè÷åñêèå íåñ÷.ñëó÷àè: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Misadventures in Cosmetic Dermatology Serum CCL23 levels are increased in patients with systemic sclerosis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] FDA Approves Low-Level Body-Sculpting Laser [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#13
15.09.2010, 14:14
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[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
- îïàñíîñòü ëàçåðíîé óêàçêè äëÿ äåòåé(ãëàçà) Kids Playing With Laser Pointers May Be Aiming for Eye Trouble Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin-inhibitors for atopic eczema: systematic review and meta-analysis of randomised controlled trials [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions: Vehicle-controlled trials indicate efficacy of proactive treatment with tacrolimus, fluticasone propionate, and methyl-prednisolone aceponate to prevent AE flares. Indirect evidence from vehicle-controlled trials suggests that twice weekly application of the potent topical corticosteroid fluticasone propionate may be more efficacious to prevent AE flares than tacrolimus ointment. Head to head trials should be conducted to confirm these results. Future studies are also needed to evaluate the long-term safety of proactive treatment of AE. - ïðîáëåìà òóáåðêóëåçà êîæè [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - ìåëàíîñêàí [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Clinical pathway for melanoma detection using comprehensive cutaneous analysis with Melanoscan® Rhett J Drugge MD, Chi Nguyen, Luciana Gliga, Elizabeth D Drugge PhD Dermatology Online Journal 16 (8): 1 - èíòåðåñíîå èññëåäîâàíèå: ìåòîòðåêñàò è êèòàéñêàÿ ìåäèöèíà(íåò ïîäòâåðæäåíèÿ ýôôåêòèâíîñòè) : Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of life [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Conclusions. Our results verify the therapeutic effect of methotrexate for the management of psoriasis. Despite widespread belief and use of TCM in Asia for the treatment of psoriasis, we were unable to confirm the efficacy of TCM in this study. What’s new in psoriasis? Analysis of the clinical significance of new guidelines and systematic reviews on psoriasis published in 2008 and 2009 [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Dermatophyte infections in Melbourne [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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#15
03.10.2010, 14:52
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Oral Propranolol for Hemangiomas of Infancy
[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Chronic pruritus [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Suicidal Ideation, Mental Health Problems, and Social Impairment Are Increased in Adolescents with Acne: A Population-Based Study [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] -ïðîãåñòåð. ÷óâñòâ. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - Prominent Degos-like Skin Lesions in a Patient with Chronic Cutaneous Lupus Erythematosus [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] - îöåíêà òÿæåñòè ïñîðèàçà(èíäåêñû â òîì ÷èñëå) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Top-Accessed Article: Psoriasis Associated With Hyperleptinemia [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Àëîïåöèÿ(ÃÀ) è ðàê ùèòîâèäíîé: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] "Dermatologists should consider palpating the thyroid in patients with alopecia or other skin diseases related to thyroid disease. Further ultrasonographic evaluation of abnormalities followed by referral to an endocrinologist or surgical oncologist for biopsy and management is prudent. Since treating this patient, we have initiated physical examination of the thyroid as a part of our standard alopecia workup." [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Thermographic Follow-up of a Mild Case of Herpes Zoster [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] The Band-Aid Sign of Trichotillomania: A Helpful Diagnostic Technique in the Setting of Hair Loss [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] An Evaluation of Long-term Outcomes in Adults With Pediatric-Onset Morphea [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Cutaneous Sclerosis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Allergic Contact Dermatitis to Synthetic Rubber Gloves [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Genital Herpes: 21st Century Update [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Pediatric Dermatology in Children of Color [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Infantile hemangiomas [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Dyshidrosiform Pemphigus Vulgaris: Report of an Unusual Case [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Áèîïðåïàðàòû: Infliximab efficacy in nail psoriasis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Post-Genomics and Skin Inflammation [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Switching biologics for psoriasis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] British Association of Dermatologists’ guidelines for the management of lichen sclerosus 2010 [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Clinical diagnosis of toenail onychomycosis is possible in some patients: cross-sectional diagnostic study and development of a diagnostic rule [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Tobacco smoking and hand eczema: a population-based study [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Contact allergy to corticosteroids and Malassezia furfur in seborrhoeic dermatitis patients [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Minoxidil: Allergic contact dermatitis: case report [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Pimecrolimus: Allergic contact dermatitis in a child: case report [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Propylene glycol: Allergic contact dermatitis: case report [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] Efficacy and safety of pimecrolimus cream in mild-moderate chronic hand dermatitis [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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Êîìáèíèðîâàííûé âèä
