Основываясь на результатах двух проведенных в США клин. исследованиях по транексамовой кислоте при обильных месячных, авторы показали, что она эффективна и при фибромиоме:
Womens Health (Lond Engl). 2013 Jul;9(4):397-403.
Efficacy and safety of oral tranexamic acid in women with heavy menstrual bleeding and fibroids.
Eder S, Baker J, Gersten J, Mabey RG, Adomako TL.
Aim: To evaluate the efficacy and safety of oral, modified-release tranexamic acid in women with heavy menstrual bleeding and fibroids. Materials & methods: This was a pooled analysis of two pivotal Phase III studies. Fibroids were evaluated by transvaginal ultrasonography. Menstrual blood loss (MBL) was measured via a validated alkaline hematin method. Results: In women with and without fibroids, mean MBL was reduced compared with placebo across all treatment cycles (p < 0.001). Within the tranexamic acid group, more statistically significant (p < 0.001) reductions in MBL compared with placebo occurred in women with fibroids than in those without fibroids. Adverse events were similar between treatment groups. Conclusion: Tranexamic acid was well tolerated and reduced MBL in women with and without fibroids.
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