Коллега, в определении доз, в частности метамизола, инструкция является нормативным актом. РКИ тут не при чем. Просто В РФ инструкции одни, у Вас другие. Вот и все. И Авентис инструкцию для РФ, указанную в Видале по Баралгину подогнал под действующие условия. И все.
Но вот по фентанилу... Miller's Anesthesiology. 7-th Edition/
Цитата:
Fentanyl
Anesthetic induction is usually achieved by combining a loading dose of fentanyl (2 to 6 µg/kg) with a sedative-hypnotic, most commonly thiopental or propofol, and a muscle relaxant. Maintenance of anesthesia can be achieved with N2O (60% to 70%) in O2, low concentrations of potent inhaled anesthetics, and additional fentanyl (intermittent boluses of 25 to 50 µg every 15 to 30 minutes or a constant infusion of 0.5 to 5.0 µg/kg/hr).
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Никак не укладывается.
Clinical Anesthesia, Barash, Paul G. 6th Edition
Цитата:
Perhaps the most common clinical use of fentanyl and its derivatives is
as an analgesic component of balanced general anesthesia. With this technique, incremental doses of fentanyl 0.5 to 2.5 µg/kg are administered intermittently as dictated by the intensity of the surgical stimulus and may be repeated approximately every 30 minutes. Generally, administration of up to 3 to 5 µg/kg/hr will allow recovery of spontaneous ventilation at the end of surgery.
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Тоже не 100 мг.