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  #45  
Старый 24.03.2004, 01:55
V. ZAITSEV V. ZAITSEV вне форума Пол мужской
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Регистрация: 25.07.2001
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V. ZAITSEV
Уважаемый Евгений Евгеньевич!
Мы так долго на форуме крутились вокруг этой темы, что предполагал, что на настоящий момент, продолжать жевать её бессмысленно.

Но так как на русском, мне не удалось с Вами объясниться, привожу английский вариант основных высказываний из предыдущего обсуждения.

Заранее согласен с критикой моего английского.

The group of scientists from Scripps Research Institute (TSRI) has published in several articles the results of the experimental works what allow them to put forward an ideas, that the immune cells for struggle with antigens can synthesize ozone and that interaction ozone with cholesterol is an important reactions for the atherosclerotic plaques formation. These papers have drawn attention of doctors practising with ozone therapy. We are considering the first conclusion as interesting, but demands the further proofs. There are more questions to the assumption, that formation of atherosclerotic plaques is accelerated owing to oxidation of cholesterol by ozone. All evidences in these works are based on detection of products of reactions, where ozone can act as an oxidizer. However such indirect identification of ozone through products of it reaction is not unequivocal. In a blood are synthesized a lot of the reactionary forms of oxygen, including singlet oxygen, hypochlorite-ion etc. These oxidizers in biochemical enzymatic reactions in vivo with mentioned cholesterol and other substances could produce the same final products what were observed Prof. P. Wentworth and his coworkers. Therefore, for example, assumption, that 5,6-secosterol is formed from cholesterol in a living body as result of oxidation by ozone, requires the further check. The same it is possible to tell on indigo oxidation by ozone. Isatin - the main reaction product - is not specific for this reaction. It can form in reaction of indigo with singlet oxygen or hypochlorite-ion Quite possible to imagine that enzymatic reactions of cholesterol with singlet oxygen can lead to 5,6-secsterol. In our opinion more specific products of ozone reactions are ozonides. Taking into account the amount of unsaturated fatty acids and their esters in blood and tissues and fast rate of ozone reaction with double bonds one can conclude that the most part of ozone, if it is really thrown out by immune cells, would be spent for this reaction. However ozonides in such systems yet are not found.

It is necessary to note, that even if the assumptions of the researchers from TSRI will prove to be true, it will be hardly possible to point out some negative consequences for ozone therapy. Single intravenous introductions of the dissolved ozone, not exceeding 0,005-0,03 mg of ozone on 1 kg of weight of the patient, hardly can add something to constant long-term emissions of ozone by immune cells in all volume of a vascular channel, if such synthesis really takes place. Not speaking that the basic part of the entered ozone is consumed, as it was mentioned, by reaction with double bonds of free fatty acids and their triglycerides with formation of ozonides. Ozonides in our opinion those metabolites, which provide with basic part of positive effects of ozone therapy.

Best regards,

Prof.. S .D. Razumovskii Dr. V.Ja.Zaitzev