Причем эффект гипокоагуляции при ОТ значительно более длительный, чем, к примеру, на фоне гепарина.
Уважаемый Владимир Яковлевич,
Некоторые работы мне тоже известны. K примеру: "As a duration time of ozone effects on the blood properties is not precisely established to date..." Leszek Tulicki et. al. May 2004.
Чтобы Вы не упрекнули меня в черном пиаре привожу дискуссионную часть работы польских озонотерапевтов без сокращений:
Ozone may induce vasodilatation (10) and increase erythrocyte deformability and filterability (11). The potential to decrease blood viscosity was demonstrated in humans with atherosclerotic ischemia of lower limbs treated with O3-AHT (controlled
study) (12), as well as intra-arterial ozone injections (uncontrolled study) (13). One possible explanation of this phenomenon points to a reduction in the fibrinogen plasma level (12). Decreased coagulation ability was found in atherosclerotic
rats subjected to intravenous ozone administration (saline controlled study), as well as in humans treated with intra-arterial ozone injections (uncontrolled study) (14,15). The significant prolongation in the recalcination time was reported in both studies, while the prothrombin time increased only in animals. The impact of ozone on hemostatic platelet function is much more complex. Ozone is known to induce platelet aggregation. During O3-AHT, however, it is avoided by the use of citrate as an anticoagulant, which chelates Ca++ and in turn decreases plasma amounts of this cation in the free form. In an elegant study comparing the effects of ozone on platelet aggregation in the presence of heparin or citrate, such a striking dose effect was seen in the case of the former agent but not for the latter (16). A recirculation in arteriovenous fistula is usually due to thrombosis or intraluminal stenosis. We assumed that the above-mentioned properties of ozone may beneficially influence this process. If so, O3-AHT could be a useful therapeutic strategy helping in the periodic improvement of fistula function in patients waiting for surgical correction. In the present study, the degree of AR was measured based on hematocrit dilution monitoring. The accuracy and repeatability of this method displays a good correlation with other techniques used in this diagnostic field (17). A decrease in the AR after O3-AHT was\ observed in the majority of subjects. However, these changes did not reach the level of statistical significance. We suppose that the study might be powerless to detect these numerical differences as being significant. Another possible explanation of this fact may be that the patients included in the study manifested no problems with their fistulas (e.g.,stenosis or partial thrombosis), so that their initial AR levels were not high. Furthermore, the method of AR determination used in the study may slightly underestimate a real degree of AR, particularly when the values are low (17). In contrast, changes in the HD adequacy index (Kt/V) after O3-AHT were not observed. This fact suggests a lack of considerable improvement in fistula function. To gain a better insight into this issue, patients with a higher level of AR should be addressed in future studies using more sensitive methods of AR assessment, such as ureabased techniques or methods which sense ultrasound velocity or conductivity. The potential beneficial influence of O3-AHT on dialyzer reuse was also considered, because changes in the hemorheological properties of blood and coagulation ability might result in decreased clotting in dialyzers. However, no such effects were found in the study. One important limitation of the study design in this regard must be mentioned here. There was no change of dialyzers for new ones at the moment of O3-AHT commencement. Thus, the assessment of dialyzer lifetime during O3-AHT was based on the calculation of the average reuse frequency of dialyzers that were often introduced to the HD treatment at the end of the O3-AHT period, and two dialyzers were sometimes used long after the end of O3-AHT. As a duration time of ozone effects on the blood properties is not precisely established to date, the study conclusion on this point should be drawn with care. [b]In summary, we have demonstrated that O3-AHT did not influence dialysis adequacy and the frequency of dialyzer reuse. The improvement of fistula function, expressed as a decrease in the AR magnitude, was not significant, although seen in the majority of patients.[b]
(AR- access recirculation.) Простите, что о диализе да в гинекологии... Но мы с Вами тут аж о каскадах говорили.
Ваша спина - прекрасный пример "testimonials", которые не могут быть использованы в качестве аргумента при разговоре с врачом или ученым. В ответ Вам говорю, что сегодня я наблюдал холодную термоядерную реакцию. Вот видел и все... Поверили?
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