Я использую ап-ту-дейт. вот например- клоназепам:
Pharmacodynamics/Kinetics
Onset of action: 20-60 minutes
Duration: Infants and young children: 6-8 hours; Adults: ≤12 hours
Absorption: Well absorbed
Distribution: Adults: Vd: 1.5-4.4 L/kg
Protein binding: 85%
Metabolism: Extensively hepatic via glucuronide and sulfate conjugation
Half-life elimination: Children: 22-33 hours; Adults: 19-50 hours
Time to peak, serum: 1-3 hours; Steady-state: 5-7 days
Excretion: Urine (<2% as unchanged drug); metabolites excreted as glucuronide or sulfate conjugates
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