- также в дополнение к предыдущему мета-анализу и информации по пробиотикам при АД(детская экзема) еще один систематический обзор :
http://forums.rusmedserv.com/showpos...25&postcount=1
Probiotics for the treatment of eczema: a systematic review
Source: Clinical & Experimental Allergy, Volume 39, Number 8, August 2009 , pp. 1117-1127
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Currently, probiotics cannot be recommended for treating eczema. The heterogeneity between studies may be attributable to probiotic strain-specific effects, which means that novel probiotic strains may still have a role in eczema management. "
- т.е. пока что как метод лечения АД(детская экзема) пробиотики не рекомендуются
- данные разнородные, поэтому потребуется время, чтобы разобраться в роли пробиотиков при лечении АД, возможно в будущем роль будет более определенной
- из Фицпатрика по пробиотикам эта разнородность данных тоже отмечена:
"2008(in general medicine)"
PROBIOTICS Perinatal administration of the probiotic Lactobacillus rhamnosus strain GG was shown to reduce the incidence of AD in at risk children during the first 2 years of life.64 Mothers were given either placebo or lactobacillus GG daily for 4 weeks before delivery and then either the mother (if breast feeding) or the infant continued with daily therapy for 6 months. In a follow-up study the same group assessed the persistence of potential to prevent AD at 4 years.65 The results suggest that the preventive effect of Lactobacillus GG on AD could extend beyond infancy. In a second study children with AD treated with two Lactobacillus strains for 6 weeks experienced improvement of their eczema compared to placebo treated patients, although their SCORAD index did not change significantly66 The treatment response was found to be more pronounced in patients with positive skin-prick tests and elevated IgE levels. Another study of children with moderate to severe AD treated for 8 weeks with L. fermentum in a placebo-controlled study showed persistent improvement in SCORAD at 16 weeks.67 These studies suggest that probiotics, or at least some lactobacillus strains, may have preventa-tive, lasting effects on the incidence of AD in a subset of patients.
More research into subgroups of responders, optimal therapy [route (i.e., directly to infant or via mother's milk); length of treatment; strain of lactobacillus], as well as mecha-nisms involved is clearly needed.68"
- т.е. данные и исследования есть, в том числе и с положительными показателями, но пока недостаточно, чтобы был однозначный ответ,
хотя использование можно считать допустимым определенных штаммов(те, по которым проводились исследования), например: "Бифиформ малыш - Lactobacillus GG, Bifidobacterium lactis BB-12, бифиформ бэби - Streptococcus thermophilus, Bifidobacterium lactis BB-12"
- также важно, что (далее цитата-перевод Вадима Валерьевича
)"на сегодняшний день не рекомендуются применять пробиотики у иммуноослабленных и критических пациентов из-за риска развития пробиотиковых инфекций"
More information is needed on safety profile of probiotics in immunocompromised state of the critically ill in view of rare reports of fungemia and sepsis and a trend toward possible increase in nosocomial infection. At present, despite theoretical potential benefits, available evidence is not conclusive to recommend probiotics for routine use in the critically ill. Indian J Pediatr. 2008 Jun;75(6):621-7. Probiotic use in the critically ill.
...various reports have documented health-damaging effects of probiotic translocation in immunocompromised patients. Nutr Rev. 2008 Apr;66(4):192-202. Safety of probiotics: translocation and infection.