[Dr.Anisimova]

- АД(атопический дерматит)-контакт с животными во время беременности-есть хорошо

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis

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Results
Maternal contact with farm animals and cats during pregnancy had a significantly protective effect on atopic dermatitis in the first 2 years of life. The risk of atopic dermatitis was reduced by more than half among children with mothers having contact with 3 or more farm animal species during pregnancy compared with children with mothers without contact (adjusted odds ratio, 0.43; 95% CI, 0.19-0.97). Elevated expression of TLR5 and TLR9 in cord blood was associated with decreased doctor diagnosis of atopic dermatitis. A significant interaction between polymorphism in TLR2 and prenatal cat exposure was observed in atopic dermatitis.
Conclusion
Maternal contact with farm animals and cats during pregnancy has a protective effect on the development of atopic dermatitis in early life, which is associated with a lower expression of innate immune receptors at birth.

Dead Sea climatotherapy effective for vitiligo treatment

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Conclusion Climatotherapy at the Dead Sea is an effective treatment modality for vitiligo. Disease duration and severity, as well as length of treatment, were the main factors found to favourably influence the clinical response.
Dead Sea Climatotherapy (DSC) has proven to have an excellent healing effect in the treatment of psoriasis and atopic dermatitis.10,11
Although evaluation criteria used were not similar to those commonly found in other studies, DSC showed better results (85.3% of patients with any level of repigmentation), than those obtained with NBUVB, as reported in the literature. In addition, it would appear that the repigmentation reached by the end of the treatment was preserved and continued to increase after leaving the Dead Sea. However, this point will need to be verified in a larger cohort of patients in the future.
It may be concluded that DSC is an effective treatment modality for vitiligo, with relatively few side-effects. It should be recommended as a potentially successful option in young patients suffering from moderate skin involvement of the disease who have the resources to pay for and dedicate 3 to 4 weeks for treatment at the Dead Sea.
- лечение поражения ногтей при псориазе-примерно одинаково в общем по эффективности (циклоспорин ложе/метотрексат-матрикс)
Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study
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Conclusion Moderate effectiveness on psoriatic nail was found in the two treatment agents and there were no significant differences in efficacy between the groups. A significant improvement was detected in methotrexate group for the nail matrix findings, and in cyclosporine group for the nail bed findings.

- стресс/кортизол и псориаз
How stress gets under the skin: cortisol and stress reactivity in psoriasis
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- к патогенезу(рецепторы) кр. волчанки(полный текст)
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Evidence for a Pathophysiological Role of Keratinocyte-Derived Type III Interferon (IFNλ) in Cutaneous Lupus Erythematosus

- ин витро коррекция фенотипа с помощью генов
Functional Correction of Type VII Collagen Expression in Dystrophic Epidermolysis Bullosa
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Thus, using trans-splicing we achieved correction of an RDEB phenotype in vitro, which marks an important step toward its application in gene therapy in vivo.

- опять про демодекс:
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Demodex folliculorum: Requirements for Understanding Its Role in Human Skin Disease
В общем можно выделить, что исследование, в том числе количественная оценка имеет смысл при биопсии кожи. Также до сих пор нет самостоятельной кожной патологии. Стоит заметить возможное отношение в патогенезу розацеа, учитывая уже накопленные сведения, особенно глазные проявления, гранулематозную, папуло/пустулезную формы, ПД(периоральеый дерматит), особенно после использования кортикостероидов(стероидный дерматит, стероидная розацеа)

- к патогенезу АД(липиды, ИЛ-25)
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Transcriptional Profiling after Lipid Raft Disruption in Keratinocytes Identifies Critical Mediators of Atopic Dermatitis Pathways
IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?
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- P. acne
Propionibacterium acnes Activates the IGF-1/IGF-1R System in the Epidermis and Induces Keratinocyte Proliferation
These results demonstrate that P. acnes can induce the formation of comedones by stimulating the IGF/IGF-1R system. Moreover, zinc downregulates this pathway.
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Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor
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