[Dr.Vad]

Уважаемые коллеги!

Опубликована моноэстрогеновая часть исследования WHI (JAMA Vol. 291 No. 14, April 14, 2004)- заключения неутешительны:

For Treatment of Menopausal Symptoms.
Hormone therapy is effective for treating menopausal symptoms, and for this indication things do look better for estrogen alone than for estrogen plus progestin. However, estrogen alone does have adverse effects, and it remains prudent to keep the dose low and the duration of treatment short.

For Prevention of Chronic Disease.
In the absence of evidence for an overall net benefit of postmenopausal treatment with estrogen alone, and with the evidence that estrogen plus progestin is harmful, neither therapy should be used for preventing disease. Although it is possible that other forms or doses of hormones could be more beneficial, this must be demonstrated in disease–end point trials before any hormone regimen can be recommended for disease prevention.

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