Исследователи из Висконсина обнаружили высокую частоту дефицита железа среди женшин 37-50 лет, ферритин менее 15 был у 70% (двух из трех!), это может поставить под сомнение распространенно бытующее мнение, что в развитых странах среди менструирующих женщин ЖД встречается в 25-35%:
Midwestern women have high rates of iron deficiency when measured by serum iron and ferritin concentrations
Iron deficiency is the most common micronutrient deficiency worldwide and is not generally considered to be of concern in healthy premenopausal women in the US.
Apparently healthy, non-smoking premenopausal women (age 37–50 years; n=118) not on hormone replacement therapy or any form of contraceptives were screened by giving fasting blood samples for a recent clinical trial. Total serum iron was measured as part of a routine chemistry profile (C20) at a local clinical laboratory and ferritin concentrations were measured (ELISA kit, Phoenix Pharmaceuticals, Inc., Burlingame, CA). C-reactive protein was also measured (EIA kit, Cayman Chemical Co., Ann Arbor, MI) to evaluate active inflammation. Dietary intakes were determined from the 2011 Harvard Grid Food Frequency Questionnaire.
Serum iron was below the standard clinical reference range (<60 μg/dL) in 23% of this cohort and 70% had serum ferritin levels below the WHO cutoff of 15 ng/mL for iron deficiency. 18% had serum ferritin below detectable levels. Only 7% of women screened had CRP>10 mg/L, suggesting that ferritin estimates were not elevated due to infection.
These data suggest that low iron may be a more prevalent issue than currently appreciated. If validated in larger and more diverse studies, it may be appropriate for health care providers to routinely assess iron status in premenopausal women.
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