Среди всех поб. эффектов реакции гиперчувствительности могут быть до 60-65%:
Hypersensitivity reactions represent 65.1% of all the reports based on the relevant MedDRA SMQs.
если же давать препарат не в запредельных дозах, то и побочных эффектов немного: 139 на 5130 или 2.7% из них менее 10% гиперчувствительности
5130 were included in a single prospective, observational, open-label study (MD 35.22, Germany, 1999, 150-450 mg per day, recommended treatment duration: 3 weeks). One hundred and thirty-nine (139) non-serious adverse reactions were reported, but there was no serious adverse reaction. A total of 11 non-serious hypersensitivity-related adverse reactions were observed (allergic dermatitis (7), pruritus (2), eye swelling (1), flushing (1)).
У индусов частота поб. эффектов на 450 мг/сут плюс НПВС =4.8%
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