По желатинам инфы не слишком много:
The various gelatin solutions have comparable volume-restoring efficacy. However, the increase in blood volume is less than the infused volume of gelatin, due to a rapid, but transient passage of gelatins in the interstitial space. Moreover, gelatins are rapidly cleared from the bloodstream
by glomerular filtration and, to a lesser part, undergo cleavage by proteases into small peptides in the reticuloendоthelial system.
Therefore, repeated infusions of gelatin are necessary to maintain adequate blood volume. This disadvantage is balanced by the fact that there are no dose limitations with gelatins as occurs with dextrans and HES solutions.
Gelatins do not accumulate in the body and appear to be almost without adverse on kidney function. Although for a long time gelatins were considered not to influence blood coagulation other than by dilution, there is some evidence that gelatins do influence platelet function and blood coagulation.
|