Микроцитоз (MCV менее 74) и ферритин менее 18 у детей на втором году жизни ассоциируется с более низким когнитивным развитием ребенка:
Five children (from n=83) had Fe deficiency (ferritin <12 µg/l) and no child had Fe deficiency anaemia (Hb<110 g/l+ferritin<12 µg/l). Children with microcytosis (MCV<74 fl, n=13) had significantly lower mean cognitive composite scores (88·5 (sd 13·3) v. 97·0 (sd 7·8), P=0·04, Cohen's d effect size=0·8) than those without microcytosis. The ferritin concentration which best predicted microcytosis was calculated as 18·4 µg/l (AUC=0·87 (95% CI 0·75, 0·98), P<0·0001, sensitivity 92 %, specificity 75 %). Using 18·5 µg/l as a threshold, children with concentrations <18·5 µg/l had significantly lower mean cognitive composite scores (92·3 (sd 10·5) v. 97·8 (sd 8·1), P=0·012, Cohen's d effect size=0·6) compared with those with ferritin ≥18·5 µg/l.
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Br J Nutr. 2017 Sep;118(5):360-367.
Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting.
McCarthy EK и соавт.
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