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Т.к. еще месяц коммерческий доступ выкладываю только оглавление и заключение.
Mycoplasmas and Ureaplasmas as Neonatal Pathogens
Ken B. Waites,1* Brenda Katz,1 and Robert L. Schelonka2
Departments of Pathology1 and Pediatrics,2 University of Alabama at Birmingham, Birmingham, Alabama 35249
INTRODUCTION
MYCOPLASMAL COLONIZATION AND DISEASE IN THE LOWER UROGENITAL TRACT OF ADULTS
MECHANISMS OF PATHOGENESIS
Localization and Cytadherence.
Secretory Products
EFFECT ON INFERTILITY AND PREGNANCY OUTCOME
Infertility
Postpartum Endometritis
Chorioamnionitis, Spontaneous Abortion, and Preterm Labor
Bacterial Vaginosis
VERTICAL TRANSMISSION
RESPIRATORY DISEASES IN INFANTS
Congenital and Neonatal Pneumonia
Pneumonia and Other Respiratory Diseases in Older Infants and Children
Association of Ureaplasma spp. with Development of Chronic Lung Disease in Preterm Neonates
SYSTEMIC INFECTIONS IN THE NEONATE
Bacteremia
Infections of the Central Nervous System.
Other Infections
DIFFERENTIAL PATHOGENICITY OF UREAPLASMA UREALYTICUM AND UREAPLASMA PARVUM.
HOST DEFENSES IN THE NEONATE
OTHER MYCOPLASMAS FOUND IN THE UROGENITAL TRACT OF ADULTS
Mycoplasma fermentans
Mycoplasma genitalium
Mycoplasma penetrans
Mycoplasma pirum
Mycoplasma pneumoniae
LABORATORY DIAGNOSIS.
Culture
Nucleic Acid Amplification
Serology
ANTIMICROBIAL SUSCEPTIBILITY
THERAPEUTIC CONSIDERATIONS
Treatment of Respiratory and Systemic Infections
Antimicrobial Treatment for Association of Ureaplasmas with BPD
CONCLUDING REMARKS
REFERENCES
CONCLUDING REMARKS
The ability of Ureaplasma spp. and M. hominis to cause pneumonia, bacteremia, and meningitis in newborns can no longer be questioned. There is strong evidence that urea- plasmas induce an inflammatory response in utero that can result in chorioamnionitis and chronic lung injury in neonates. The association of Ureaplasma spp. with BPD has been supported by the majority of observational studies, but proof of causality is still lacking. Whether antimicrobial treatment of ureaplasma-colonized infants can effectively eradicate these organisms and reduce the incidence of BPD will require a large, multicenter, randomized treatment trial. The availability of powerful molecular diagnostic tools to complement culture for the detection and characterization of ureaplasmas in clin- ical specimens has enabled the designation of the two Ureaplasma biovars as individual species, but additional work must be done to establish whether there is differential pathogenicity between the Ureaplasma spp. The role of Ureaplasma spp. in preterm labor, the frequency and morbidities associated with genital mycoplasmas in systemic diseases in neonates, and the relationship of host immune status to successful therapy all warrant further investigation.
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