Эффект ЖДА на число тромбоцитов среди доноров - в среднем у доноров с ЖДА число тромбоцитов было на 20 больше, чем с нормальным ферритином и коррекция ЖДА понижала тромбоциты на 20:
Whole blood donors deferred for finger-stick hemoglobin levels less than 12.5 g/dL were evaluated by complete blood count and serum iron panel before and after oral iron treatment. Group assignment for iron depletion was based on serum ferritin cutoffs of less than 20 µg/L for women and less than 30 µg/L for men or was based on changes in serum ferritin levels after iron replacement.
Among 1273 Hb-deferred whole blood donors, 55% (619 of 1128) of the women and 70% (102 of 145) of the men were iron depleted. Iron-depleted donors had higher platelet counts compared with donors who had normal ferritin levels (women: 286 vs. 268 × 10/3/µL; p < 0.0001; men: 246 vs. 222 × 10/3/µL; p = 0.0454). Only 4.4% of iron-depleted donors had thrombocytosis (> 400 × 10/3/µL) compared with 2.0% of donors who had normal ferritin levels (p = 0.017). Iron replacement decreased platelet counts in iron-depleted female donors (mean, -19,800/µL; interquartile range, 8000 to -45,000/μL), but not in donors who had normal or stable ferritin levels.
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Transfusion. 2016 Nov 29.
The effect of iron balance on platelet counts in blood donors.
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