20.05.2003, 14:50
|
|
Модератор форума по гематологии
|
|
Регистрация: 16.01.2003
Город: Хьюстон, Техас
Сообщений: 80,394
Поблагодарили 33,236 раз(а) за 31,585 сообщений
|
|
Ув. Ляля!
И хотя уреаплазма более чувствительна к макролидам (группу, обьединяющую Вами указанные препараты), но похоже, что к азитромицину (сумамед) уреаплазмы более чувствительны, менее устойчивы:
Chemotherapy 2003 May;49(1-2):39-43
Assessment of antibiotic susceptibility of Ureaplasma urealyticum from prostitutes and outpatient clinic patients using the E-test and agar dilution method.
Cakan H, Polat E, Kocazeybek B, Ocal P, Cepni I, Aslan M, Salihoglu F, Altas K.
In this study, a total of 647 vaginal discharge samples were examined. Ureaplasma urealyticum growth was seen in 68 samples (10.5%). The antibiotic sensitivity of 30 types of U.urealyticum was determined with the E-test and agar dilution method. With the agar dilution method, all types were sensitive to ciprofloxacin and ofloxacin (MIC 0.94 microg/ml), tetracycline (MIC 0.125 microg/ml) and doxycycline (MIC 0.125 and 0.190 microg/ml). Furthermore, with the agar dilution method, 18 types (60%) were resistant to roxithromycin and 12 (40%) were sensitive (MIC 12 microg/ml); 3 types (10%) were resistant to erythromycin and 27 (90%) were sensitive (MIC 12 microg/ml); 9 types (30%) were resistant to clarithromycin and 21 (70%) were sensitive (MIC 12 microg/ml), and all types were sensitive to azithromycin (MIC 14 microg/ml).
Часто используется однократный прием сумамеда 1 грамм, но похоже при длительных клин.проявлениях(более 3 нед.) лучше по 0,5 g 2 раза в день в течение 6 дней.
: Drugs Exp Clin Res 2001;27(4):135-9
Azithromycin and doxycycline in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum: significance of duration of clinical symptoms.
Skerk V, Schonwald S, Krhen I, Rusinovic M, Strapac Z, Vukovic J.
One hundred ninety-two female patients with acute urethral syndrome caused by Ureaplasma urealyticum were examined. First, patients were divided into two groups: those with clinical symptoms present for less than 3 weeks before the start of treatment and those with clinical symptoms 3 weeks or longer before the beginning of therapy. The patients were then further divided into groups and randomized to receive azithromycin once daily in a single dose of 1 g or 500 mg once daily for 6 days, or to receive doxycycline 100 mg b.i.d. for 14 days or 100 mg b.i.d. for 7 days (eight study groups in all). Clinical and bacteriological efficacy were evaluated 3 weeks after the end of therapy. In the group of patients with disease symptoms lasting for 3 weeks or longer, eradication and clinical cure rates were significantly higher after the administration of azithromycin at a dose of 1 x 500 mg/6 days than after a single dose of 1 g (p < 0.001).
Препаратами второй линии являются фторхинолоны, тетрациклины (последние Вам не очень, ибо часто вызывают дисбактериоз).
для профилактики дисбактериоза во время лечения АБ настоятельно вам рекомендую препараты (иогурты), содержащие живые штаммы бифидобактерий/лактобактерий.
|