Вот такой 3-летнее наблюдение за беременными с ЖДА из Австралии, у которых ее лечение было исключительно препаратом железа внутрь или же вначале одна в/в иньекция аналога Венофера, а затем прием железа внутрь:
Two hundred women matched for haemoglobin concentration and serum ferritin level were recruited. Patients were randomized to daily oral ferrous sulphate 250 mg (elemental iron 80 mg) with or without a single intravenous iron polymaltose infusion...
Prior to delivery, the intravenous plus oral iron arm was superior to the oral iron only arm as measured by the increase in haemoglobin level (mean of 19.5 g/L vs. 12 g/L; P < 0.001); the increase in mean serum ferritin level (222 microg/L vs. 18 ug/L; P < 0.001); and the percentage of mothers with ferritin levels below 30 microg/L (4.5% vs. 79%; P < 0.001). A single dose of intravenous iron polymaltose was well tolerated without significant side effects.//J Intern Med. 2010 Sep;268(3):286-95.
через 3 года:
Patients who received intravenous iron demonstrated significantly higher haemoglobin and serum ferritin levels (p<0.001). There were strong associations between iron status and a number of the HRQoL parameters, with improved general health (p<0.001), improved vitality (physical energy) (p<0.001), less psychological downheartedness (p=0.005), less clinical depression (p=0.003) and overall improved mental health (p<0.001). The duration of breastfeeding was longer (p=0.046) in the intravenous iron group. The babies born in both groups recorded similarly on APEG growth chart assessments...
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BMJ Open. 2012 Oct 18;2(5). Three-year follow-up of a randomised clinical trial of intravenous versus oral iron for anaemia in pregnancy.
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