Систематический обзор с метаанализом:
Ann Plast Surg. 2015 Feb;74(2):256-62. doi: 10.1097/SAP.0000000000000390.
Local administration of β-blockers for infantile hemangiomas: a systematic review and meta-analysis.
Ovadia SA1, Landy DC, Cohen ER, Yang EY, Thaller SR.
Цитата:
CONCLUSIONS:
Topically administered β-blockers are an effective treatment for superficial IHs that pose few adverse effects and should be considered for primary treatment.
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Предлагается в определенных случаях как первая линия лечения!
Абстракт: [
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Небольшой анализ и более осторожное резюме от Европейской экспертной группы
Eur J Pediatr. 2015 Jul;174(7):855-65. doi: 10.1007/s00431-015-2570-0. Epub 2015 May 29.
Treatment of infantile haemangiomas: recommendations of a European expert group.
Hoeger PH1, Harper JI, Baselga E, Bonnet D, Boon LM, Atti MC, El Hachem M, Oranje AP, Rubin AT, Weibel L, Léauté-Labrèze C.
(Есть полный текст, если надо - скину)
Цитата:
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As long as safety and efficacy have not been studied more systematically, topical beta blockers cannot be recommended as a standard of therapy. They have, on the other hand, the potential to become the first-line agent for the treatment of small and superficial IH located in problematic^ regions, thus obviating systemic treatment in a significant minority of children with IH.
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