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A Look Back at the Effect of Varicella Vaccination on Varicella Deaths
In just over a decade, the average annual mortality rate for varicella-related deaths in the U.S. has declined 88%.

During the first 6 years after the 1995 licensure of the varicella vaccine, varicella-related mortality in the U.S. dropped 66% (from 105 annual deaths to 39 deaths). This study examined varicella mortality from 2002 through 2007 — a period when vaccine coverage increased to about 90% of children aged 19 to 35 months.

In 2002, varicella was listed in 32 records as the underlying cause of death. The annual number of varicella deaths in 2003 through 2007 ranged from 13 to 19; this represents an 88% decline in the average mortality rate from 0.41 per million in the immediate prevaccine years (1990–1994) to 0.05 per million in 2005–2007. The decline was greatest in patients younger than 20 (97%) but was also apparent in older patients (age, 20–49: 90%; age, >50: 67%). Only 11% of patients whose deaths were related to varicella had preexisting high-risk medical conditions (all were malignancies).
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Near Elimination of Varicella Deaths in the US After Implementation of the Vaccination Program.
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