Недавний мета-анализ подтверждает результаты бесполезности НМГ у женшин с тромбофилиями:
We performed a meta-analysis of randomized controlled trials comparing LMWH versus no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared to no LMWH (RR 0.81, 95% CI, 0.55 to 1.19, p=0.28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.
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Blood. 2016 Feb 2.
A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia.
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