[Dr.Vad]

Уважаемый Михаил Владимирович!

Как-то не емко рекомендовать хинина сульфат при сетевом общении: препарат небезопасен (вызывает ДВС, ТТП/ГУС), хотя и считается наиболее рекомендуемым при таком состоянии.

Действительно, в зависимости от причин ночных судорог в ногах эффективным может быть и др. виды лечения, напр.:

Angiology. 2004 Mar-Apr;55(2):147-54.

Calcium dobesilate for chronic venous insufficiency: a systematic review.

Ciapponi A, Laffaire E, Roque M.

Family and Preventive Medicine Division, Hospital Italiano de Buenos Aires, Universidad de Buenos Aires, Argentina.

Chronic venous insufficiency (CVI) causes much discomfort and sick leave. Many randomized clinical trials (RCTs) have shown a beneficial effect of calcium dobesilate, but consensus is lacking about efficacy and safety. The authors report a meta-analysis of the effectiveness and safety of calcium dobesilate in CVI. Ten RCTs (778 patients) in which calcium dobesilate for CVI was compared with placebo met the inclusion criteria. Only 3 trials (608 patients) were of good methodological quality. Calcium dobesilate significantly improved night cramps and discomfort nearly twice as well as placebo, with the number needed to treat (NNT) being 8 (95% CI 4-50) and 4 (95% CI 3-7), respectively. Frequency of adverse events was not significantly different from placebo... No difference in effect was found for different doses of calcium dobesilate (1,000 or 1,500 mg/day).

Недавний тематич. обзор выслал Вам на мейл:

Butler JV, Mulkerrin EC, O'Keeffe ST.
Nocturnal leg cramps in older people.
Postgrad Med J. 2002 Oct;78(924):596-8.