[Sereda Andrey]

По поводу мазей на раны, заживающие первичным натяжением:

Prevention of Perioperative Infection

Nicholas Fletcher, D'Mitri Sofianos, Marschall Brantling Berkes and William T. Obremskey
2007;89:1605-1618. doi:10.2106/JBJS.F.00901 J Bone Joint Surg Am.

A variety of creams, ointments, and solutions have been
advocated as means of propagating wound epithelialization.
Cooper et al. evaluated the toxicity of several antimicrobial
agents and found povidone-iodine to be significantly more
toxic to fibroblasts than other agents (p < 0.05). Kramer
showed a detrimental effect of povidone-iodine on wound-
healing. Triple antibiotic ointment was shown to increase
re-epithelialization by 25% in an animal model. In a prospective, randomized, controlled trial evaluating 426 uncomplicated wounds, the infection rates in the groups treated with bacitracin ointment (six of 109, 5.5%) or triple antibiotic ointment (five of 110, 4.5%) were lower than those in the
groups treated with silver sulfadiazine (twelve of ninety-nine, 12.1%) or petroleum (nineteen of 108, 17.6%) (p = 0.0034)
Broad-spectrum ointments provide occlusion and increase
epithelialization while the wound heals.
The majority of evidence-based reports on wound
dressings have been published in the plastic surgery and der-
matology literature. Current recommendations for the man-
agement of uninfected surgical wounds include the use of a
three-layered surgical dressing. The use of a triple antibiotic
ointment can be followed by application of a nonadherent,
hydrophilic layer. The second layer should be absorptive, and
the final layer should be occlusive to contain the underlying
physiologic milieu. The dressing may be removed as early as
the first postoperative day, and the wound may be gently
cleaned with water or saline solution (Table IV).
И мази "тройной антибиотик" включили в группу рекомендаций степени В:
1.Surgical dressings may be removed as early as the first postoperative day without any apparent increase in the risk of infection
2.Triple antibiotic ointment increases epithelialization and has been associated with fewer infections in uncomplicated clean surgical wounds
Вероятно леврмеколь ближе к этому, чем спитовка.