#1
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Ïðîáèîòèêè.
Conclusions: This probiotics mixture reduced the severity of diarrhea and length of hospital stay in children with acute diarrhea. In addition to restoring beneficial intestinal flora, probiotics may enhance host protective immunity such as down-regulation of pro-inflammatory cytokines and up-regulation of anti-inflammatory cytokines.
Posted: 03/04/2010; Pediatr Infect Dis J. 2010;29(2):135-138 Ïîëíîñòüþ çäåñü [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] |
#2
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Âîò åùå îäíà ñòàòüÿ îá ýôôåêòèâíîñòè ïðîáèîòèêîâ.
[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] |
#3
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Enteral supplementation of probiotics reduces the risk of severe NEC and mortality in preterm infants. A large randomized controlled trial is required to investigate the benefit and safety profile of probiotics supplementation in ELBW infants. Àáñòðàêò:[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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 ïðîäîëæåíèè òåìû Clinical Report: Probiotics and Prebiotics in Pediatrics
PDF full: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] |
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Òóò âûäåðæêè èç áåñåäû ñ Dr. Dan W. Thomas - îäíèì èç àâòîðîâ ðàáîòû ññûëêó íà êîòîðóþ ïðèâåë êîëëåãà.
Medscape ...what would you suggest primary care providers advise parents who choose to bottle-feed? Should infant formula supplemented with probiotics be recommended? Dr. Thomas: No one can answer this question at this time. The health benefits of feeding infant formula containing probiotics and/or prebiotics are unproven. In essence, this report challenges industry and healthcare researchers to conduct high-quality, evidence-based studies to answer these questions. Medscape:And what about advice to parents of older children who would like to give probiotics to their child? Dr. Thomas: Outside of the specific situations outlined in this report where there is evidence of benefit, the answer to this question, too, is relatively unknown and will have to await further research. While the results indicate that there is modest benefit with use of probiotics to prevent AGE in infants and children, the available data do not support routine use to prevent nosocomial rotavirus diarrhea in children attending daycare. Medscape: What does the report say about use of probiotics in the prevention and treatment of antibiotic-associated diarrhea? Dan W. Thomas However, there have been no published RCTs examining probiotics for the treatment of antibiotic-associated diarrhea in children, including Clostridium difficile antibiotic-associated diarrhea, and therefore their use presently cannot be recommended for pediatric patients. Medscape: Can you discuss the report's recommendations regarding use of probiotics in other GI conditions such as infantile colic and irritable bowel syndrome? Dan W. Thomas While the results were encouraging, finding less crying within 1 week of initiation of Lactobacillus reuteri when compared with simethicone, probiotics cannot yet be routinely recommended ...Studies of efficacy in treating constipation have been less positive, however, and they are not recommended at this time for treatment of this condition in children. Medscape: What about use in more serious GI conditions such as inflammatory bowel disease (IBD) or necrotizing enterocolitis (NEC)? Dan W. Thomas more research is needed and probiotics cannot be routinely recommend at this time. At this time, their use cannot be recommended for children with Crohn disease. There is evidence to support the use of probiotics to prevent NEC in preterm infants weighing more than 1000 g at birth.[5] However, there remain many unanswered questions over the use of probiotics for prevention of NEC, including overall safety. Further study is recommended before routine utilization of probiotics for this purpose can be recommended. Medscape:The clinical report also discussed use of probiotics for non-gastrointestinal conditions, particularly atopic disease. Can you share some of these recommendations? Dan W. Thomas That position was reiterated in a 2010 review that concluded that there was not enough evidence to support the use of probiotics, prebiotics, or synbiotics in the prevention or treatment of allergic dermatitis in children.[7] Medscape:The clinical report also discussed use of these agents in prevention and management of extraintestinal, primarily respiratory, infection. Can you describe these results? Dan W. Thomas No studies have found a benefit from administration of probiotics to treat these infections. |
#6
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À ÿ âîò îáðàòèëà âíèìàíèå íà äðóãèå âûäåðæêè
Öèòàòà:
Öèòàòà:
Ñîáñòâåííî ÿ ïîíÿëà ýòó ïóáëèêàöèþ òàê: Ïðîôèëàêòèêà ÀÀÄ -âîçìîæíî. Ëå÷åíèå ðîòàâèðóñíîé èíôåêöèè- âîçìîæíî . Âñ¸ îñòàëüíîå: àòîïèè, ÂÇÊ, ëå÷åíèå ÀÀÄ, áàêòåðèàëüíûå ïîíîñû, ïðîôèëàêòèêà ÎÐÂÈ , ïðîñòî òàê â ñìåñè- ïîêà íåò. |
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Probiotic Improves Colic in Breastfed Infants
By Will Boggs, MD NEW YORK (Reuters Health) Sep 26 - The probiotic Lactobacillus reuteri DSM 17938 improves colic in infants who are exclusively or predominantly breastfed, a new study shows. "Given the lack of effective therapy for infantile colic and the generally good safety profile of probiotics in otherwise healthy populations, the use of L. reuteri DSM 17938 could be discussed with caregivers," Dr. Hania Szajewska from the Medical University of Warsaw in Poland told Reuters Health by email. A number of therapies for colic have been tried (modified formulas, herbal teas, music, and the like), but none so far has been proven conclusively to be effective. Encouraged by a recent double-blind randomized trial that showed improvement of colic symptoms in breastfed infants, Dr. Szajewska and colleagues compared the effectiveness of L. reuteri DSM 17938 with placebo in the treatment of 80 breastfed infants with infantile colic. Significantly more infants in the probiotic group than in the placebo group experienced treatment success (a reduction in the daily average crying time of at least 50%) beginning at day 7 and continuing throughout the 28-day study. At day 14, for instance, 30 of 40 kids given probiotics experienced treatment success versus only 7 of 40 in the placebo group, for a number needed to treat of 2. Median duration of daily crying was also significantly improved by probiotic treatment at all time points after baseline. Secondary outcomes (parental perception of colic severity and family quality of life) were also significantly better in the probiotic group than in the placebo group. According to the September 17th report in The Journal of Pediatrics, there were no adverse events associated with either treatment. The researchers say that possible explanations for these improvements include L. reuteri's effects on gut motility and function, colonic sensory nerves, colon contractile activity, and pain perception, as well as possible anti-inflammatory effects. However, as Dr. Szajewska notes, "The mechanism of action of L. reuteri for treating infantile colic has yet to be elucidated." "The necessity of treating this self-limiting condition may be questioned," the authors conclude. "However, if one wants to modify the natural history of infantile colic, the use of L. reuteri DSM 17938 could be discussed with caregivers." "Future studies," they add, "should clarify the role of L. reuteri DSM 17938 in the management of infantile colic in formula-fed infants." The study was funded by the Medical University of Warsaw, which had received a donation from BioGaia AB, the manufacturer of L. reuteri DSM 17938. SOURCE: [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] J Pediatr 2012.[Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ] ÇÛ: ïîëó÷èëà ñ ðàññûëêîé. |
#8
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Äàæå â UpToDate ïðîáèîòèêàì ïîñâÿùåíà öåëàÿ ãëàâà. [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
Îíè ðåêîìåíäóþò Saccharomyces boulardii äîáàâëÿòü ê ýðàäèêàöèîííîé òåðàïèè H.pylori. Ïðè ýòîì äëÿ áîëüøèíñòâà àìåðèêàíñêèõ âðà÷åé Uptodate ÷óòü ëè íå ïîñëåäíÿÿ èíñòàíöèÿ. Êòî áû ìîã ïîäóìàòü î òàêîì åùå íåñêîëüêî ëåò íàçàä... (ÿ èìåþ â âèäó ïîÿâëåíèå óñïåøíûõ òðèàëîâ ïî ïðîáèîòèêàì íà ñòðàíèöàõ JAMA, íà ìåäñêåéïå, è â Ñàìîì Àïòóäåéòå))) ò.å. evidence ïî íåêîòîðûì çàáîëåâàíèÿì äàâíî áûë, íî â ïîñëåäíèå ãîäû ïðÿìî ïðîðûâ, èìõî |
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Î ïðîáèîòèêàõ äëÿ ëå÷åíèÿ è ïðîôèëàêòèêè èíôåêöèîííûõ áîëåçíåé - îáçîð íà óêðàèíñêîì (àìåðèêàíñêîå ñîîáùåñòâî äèåòîëîãèè) [Ññûëêè äîñòóïíû òîëüêî çàðåãèñòðèðîâàííûì ïîëüçîâàòåëÿì ]
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