Мета-анализ в Ланцете: фолиевая снижает риск первичного инсульта на 18%

[Dr.Vad]

В текущем Ланцете опубликован мета-анализ, показывающий, что фолиевая эффективна для первичной профилактики инсульта:

Folic acid supplementation significantly reduced the risk of stroke by 18% (RR 0·82, 95% CI 0·68–1·00; p=0·045). In the stratified analyses, a greater beneficial effect was seen in those trials with a treatment duration of more than 36 months (0·71, 0·57–0·87; p=0·001), a decrease in the concentration of homocysteine of more than 20% (0·77, 0·63–0·94; p=0·012), no fortification or partly fortified grain (0·75, 0·62–0·91; p=0·003), and no history of stroke (0·75, 0·62–0·90; p=0·002). In the corresponding comparison groups, the estimated RRs were attenuated and insignificant.

Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
Lancet. 2007;369:1876-1882

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