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BMJ |16 FEBRUARY 2013 | VOLUME 346
Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study Department of Surgical Sciences, Section of Orthopedics, Uppsala University, SE-751 85 Uppsala, Sweden Department of Medical Sciences, Section of Clinical Pharmacology, Uppsala University, Uppsala, Sweden Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden STUDY QUESTION What is the association of long term intake of dietary and supplemental calcium with mortality from all causes and cardiovascular disease? SUMMARY ANSWER High intakes of calcium (>1400 mg/day) are associated with higher mortality from all causes and cardiovascular disease. WHAT IS KNOWN AND WHAT THIS PAPER ADDS A low calcium intake is associated with a higher risk of fracture, stroke, and fatal ischaemic heart disease. Metaanalyses of randomised studies have, however, shown a higher risk of ischaemic heart disease and stroke with use of calcium supplements. In our Swedish cohort study of women, high intakes of calcium were associated with higher mortality from all causes, cardiovascular disease, and ischaemic heart disease but not from stroke. ++++++++++++++++++++++++++++++++++++++++++++++++++ ++++++ Generalisability to other populations Our results might not apply to people of other ethnic origins or to men |