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#1
25.11.2005, 20:18
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Артемизинин
Уважаемые коллеги, обращаюсь к вам с просьбой. Что вам известно о применении такого препарата, как артемизинин (artemisinin) и его производных (artesunate, artemether) в лечении онкологических заболеваний, в частности меланомы сосудистой оболочки глаза. Имеются ли возможности приобретения препаратов артемизинина в России (по моим данным препарат в России не зарегистрирован, так ли это?) и как это сделать. Можно ли заказать препарат из-за рубежа?
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#2
25.11.2005, 20:32
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Цитата:
Artemisinin-based combination treatments (ACTs) Artemether-lumefantrine Currently the only internationally licenced coformulated ACT. Available in Asia and Africa Artesunate and amodiaquine Currently copackaged. Adopted as policy by some African counties. Effective where amodiaquine resistance is low Dihydroartemisinin-piperaquine Coformulated drug that has been used widely in Asia and is presently being assessed in a new formulation for licensing Artesunate and mefloquine Mainstay of antimalarial drug policy in much of southeast Asia. Regarded as too expensive for the African market Artesunate and sulfadoxine-pyrimethamine Treatment used in some Asian countries (eg, Afghanistan). Ineffective where sulfadoxine-pyrimethamine has failed Dihydroartemisinin-napthoquine-trimethoprim New formulation used in China and Vietnam. Early reports are encouraging Цитата:
В Медлайне есть ссылки?
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#3
27.11.2005, 17:45
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Есть одна:
Oncol Rep. 2005 Dec;14(6):1599-603. Related Articles, Links Artesunate in the treatment of metastatic uveal melanoma - first experiences. Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO, Baur A, Schuler G. Dermatologische Klinik mit Poliklinik, Hartmannstr. 14, D-91052 Erlangen, Germany. Artesunate (ART) is a derivative of artemisinin, the active principle of the Chinese herb Artemisia annua L. Artesunate is approved for the treatment of multidrug-resistant malaria and has an excellent safety profile. It has been shown that Artesunate, apart from its anti-malarial activity, has cytotoxic effects on a number of human cancer cell lines, including leukemia, colon cancer and melanoma. We report on the first long-term treatment of two cancer patients with ART in combination with standard chemotherapy. These patients with metastatic uveal melanoma were treated on a compassionate-use basis, after standard chemotherapy alone was ineffective in stopping tumor growth. The therapy-regimen was well tolerated with no additional side effects other than those caused by standard chemotherapy alone. One patient experienced a temporary response after the addition of ART to Fotemustine while the disease was progressing under therapy with Fotemustine alone. The second patient first experienced a stabilization of the disease after the addition of ART to Dacarbazine, followed by objective regressions of splenic and lung metastases. This patient is still alive 47 months after first diagnosis of stage IV uveal melanoma, a situation with a median survival of 2-5 months. Despite the small number of treated patients, ART might be a promising adjuvant drug for the treatment of melanoma and possibly other tumors in combination with standard chemotherapy. Its good tolerability and lack of serious side effects will facilitate prospective randomized trials in the near future.
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#4
27.11.2005, 17:51
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1: Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO, Baur A, Schuler G. Related Articles, Links
Artesunate in the treatment of metastatic uveal melanoma - first experiences. Oncol Rep. 2005 Dec;14(6):1599-603. PMID: 16273263 [PubMed - in process] 2: Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Related Articles, Links Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J Med Chem. 2005 Jul 28;48(15):4953-61. PMID: 16033274 [PubMed - indexed for MEDLINE] 3: Efferth T. Related Articles, Links Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy. Drug Resist Updat. 2005 Feb-Apr;8(1-2):85-97. Review. PMID: 15878303 [PubMed - indexed for MEDLINE] 4: Efferth T, Volm M. Related Articles, Links Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In Vivo. 2005 Jan-Feb;19(1):225-32. PMID: 15796179 [PubMed - indexed for MEDLINE] 5: He XL, Liu Z. Related Articles,Links [Protection of artesunate on activation and injury of vascular endothelial cells induced by lipopolysaccharide] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Dec;24(12):1110-3. Chinese. PMID: 15658657 [PubMed - indexed for MEDLINE] 6: Dell'Eva R, Pfeffer U, Vene R, Anfosso L, Forlani A, Albini A, Efferth T. Related Articles,Links Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. Biochem Pharmacol. 2004 Dec 15;68(12):2359-66. PMID: 15548382 [PubMed - indexed for MEDLINE] 7: Efferth T, Benakis A, Romero MR, Tomicic M, Rauh R, Steinbach D, Hafer R, Stamminger T, Oesch F, Kaina B, Marschall M. Related Articles,Links Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med. 2004 Oct 1;37(7):998-1009. PMID: 15336316 [PubMed - indexed for MEDLINE] 8: Efferth T, Oesch F. Related Articles,Links Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines. Biochem Pharmacol. 2004 Jul 1;68(1):3-10. PMID: 15183112 [PubMed - indexed for MEDLINE] 9: Rinner B, Siegl V, Purstner P, Efferth T, Brem B, Greger H, Pfragner R. Related Articles,Links Activity of novel plant extracts against medullary thyroid carcinoma cells. Anticancer Res. 2004 Mar-Apr;24(2A):495-500. PMID: 15152949 [PubMed - indexed for MEDLINE] 10: Chen HH, Zhou HJ. Related Articles, Links [Inhibitory effects of artesunate on angiogenesis] Yao Xue Xue Bao. 2004 Jan;39(1):29-33. Chinese. PMID: 15127577 [PubMed - indexed for MEDLINE] 11: Efferth T, Ramirez T, Gebhart E, Halatsch ME. Related Articles,Links Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774. Biochem Pharmacol. 2004 May 1;67(9):1689-700. PMID: 15081868 [PubMed - indexed for MEDLINE] 12: Chen HH, Zhou HJ, Wu GD, Lou XE. Related Articles, Links Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1. Pharmacology. 2004 May;71(1):1-9. PMID: 15051917 [PubMed - indexed for MEDLINE] 13: Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Related Articles,Links Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. J Med Chem. 2004 Feb 26;47(5):1299-301. PMID: 14971910 [PubMed - indexed for MEDLINE] 14: Efferth T, Briehl MM, Tome ME. Related Articles, Links Role of antioxidant genes for the activity of artesunate against tumor cells. Int J Oncol. 2003 Oct;23(4):1231-5. PMID: 12964009 [PubMed - indexed for MEDLINE] 15: Efferth T, Sauerbrey A, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD, Ross DD, Funk JO. Related Articles,Links Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol. 2003 Aug;64(2):382-94. PMID: 12869643 [PubMed - indexed for MEDLINE] 16: Chen HH, Zhou HJ, Fang X. Related Articles, Links Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res. 2003 Sep;48(3):231-6. PMID: 12860439 [PubMed - indexed for MEDLINE] 17: Wang Q, Wu LM, Li AY, Zhao Y, Wang NP. Related Articles,Links [Experimental studies of antitumor effect of artesunate on liver cancer] Zhongguo Zhong Yao Za Zhi. 2001 Oct;26(10):707-8, 720. Chinese. PMID: 12776323 [PubMed - indexed for MEDLINE] 18: Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Related Articles, Links Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. J Med Chem. 2003 Mar 13;46(6):1060-5. PMID: 12620083 [PubMed - indexed for MEDLINE] 19: Lou XE, Zhou HJ. Related Articles, Links [Effects of artesunate on progestrone estrogen content and decidua in rats] Yao Xue Xue Bao. 2001 Apr;36(4):254-7. Chinese. PMID: 12580051 [PubMed - indexed for MEDLINE] 20: Wang Q, Wu LM, Zhao Y, Zhang XL, Wang NP. Related Articles, Links [The anticancer effect of artesunate and its mechanism] Yao Xue Xue Bao. 2002 Jun;37(6):477-8. Chinese. PMID: 12579811 [PubMed - indexed for MEDLINE]
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