еще две публикации на тему - риск тромбоза у высокорослых отмечался даже среди родных братьев и сестер - разница в 10 см повышала риск на треть:
Compared with the tallest women (>185 cm) and men (>190 cm), there was a graded decreased risk by lower height for both men and women. The risk was lowest in women and men with the shortest stature (<155 and <160 cm, respectively): hazard ratios=0.31 (95% confidence interval, 0.22-0.42) and 0.35 (95% confidence interval, 0.22-0.55), respectively. There was a graded association also in the cosibling design comparing siblings with varying degree of discordance for height (reference was the taller sibling): ≥10 cm difference between brothers hazard ratios=0.69 (95% confidence interval, 0.61-0.78) and sisters hazard ratios=0.65 (95% confidence interval, 0.52-0.80), respectively.
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Circ Cardiovasc Genet. 2017 Oct;10(5).
Body Height and Incident Risk of Venous Thromboembolism: A Cosibling Design.
Наличие тромбофилии не усиливало риск тромбоза у высокорослых, как это отмечалось при ожирении:
The VTE risk increased by increasing category of body height, and subjects with height ≥ 178 cm had a two-fold higher VTE risk (HR 2.03; 95% confidence interval [CI] 1.51-2.73) than those with height ≤ 165 cm. The VTE risk also increased across categories of risk alleles. However, the combination of a tall stature and risk alleles, either individual SNPs or risk score, did not result in an excess VTE risk. Subjects with four or more risk alleles and height ≥ 178 cm had a two-fold (HR 2.08; 95% CI 1.24-3.52) higher VTE risk than subjects ≤ 165 cm with no risk allele or one risk allele.
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J Thromb Haemost. 2018 Jan;16(1):83-89.
Joint effects of prothrombotic genotypes and body height on the risk of venous thromboembolism: the Tromsø study.
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Искренне,
Вадим Валерьевич.
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