Дополнительная информация к одному из вопросов ув. д-ра Гилярова.
© Springer-Verlag 2001
Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease
R. Giunta1, A. Coppola1, C. Luongo2, A. Sammartino2, S. Guastafierro3, contact1contact1, A. Grassia1, L. Giunta1, L. Mascolo2, A. Tirelli3 and L. Coppola1
(1) Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 2, 80138 Naples, Italy
(2) Hyperbaric Medicine Service, Second University of Naples, Piazza L. Miraglia, 2, 80138 Naples, Italy
(3) Department of Hematology, Second University of Naples, Largo Madonna delle Grazie, 2, 80138 Naples, Italy
Abstract. Twenty-seven subjects suffering from peripheral occlusive arterial disease (POAD, clinical stage II-III according to Fontaine) were enrolled in this study to evaluate the effect of oxygen-ozone therapy upon hemorheological parameters and hemoglobin-oxygen affinity in patients with POAD. All patients underwent a major ozonized autohemotransfusion consisting of the slow reinfusion of 100 ml of autologous blood, previously exposed to a O2-O3 mixture in a glass box for 10 min. Whole blood viscosity, erythrocyte filterability, hematocrit, and fibrinogen levels were assessed at the basal time and 30 min after the reinfusion of ozonized blood. At the same time p50 standard (p50std) values (an indicator of hemoglobin-oxygen affinity) and plasma values of malonyl dialdehyde (MDA, an indicator of lipid peroxidation) were evaluated. At the baseline, patients had significantly higher (p<0.05-p<0.001) whole blood viscosity, MDA, and p50std values and significantly lower blood filterability (p<0.01) as compared with 20 matched healthy volunteers (controls). Thirty minutes after the end of a major autohemotransfusion, whole blood viscosity significantly decreased (p<0.01). This was accompanied by a significant fall in plasma fibrinogen level (p<0.01) with no change in hematocrit. Blood filterability, MDA plasma level, and p50std values increased significantly at the same time (p<0.01-p<0.005). The 2,3-DPG value did not change significantly. No significant changes occurred when the same patients received a non-ozonized autohemotransfusion (control test). In conclusion, ozonized autohemotransfusion may be useful to improve both the poor rheological properties of the blood and the oxygen delivery to tissues in patients suffering from POAD.
По второй работе « Verrazo G, Coppola L, Luongo C, Sammartino A, Giunta R, Grassia A, Ragone R, Tirelli A. Hyperbaric oxygen, oxygen-ozone therapy, and rheological parameters of blood in patients with peripheral occlusive arterial disease. Undersea and Hyperbaric Medicine 1995; 22:17-22» - я не имею
в электроном виде даже abstract.
Но главный вывод работы: Oxygen-ozone, but not hyperbaric oxygen, altered rheological parameters in patients with peripheral occlusive vascular disease.
Следует напомнить, что при озонотерапии различных форм кислорода в организм попадает ничтожно мало, по сравнению ГБО.
P. S. Прошу the vain turkey cock своими комментариями не беспокоить.