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SYSADOA (glucosamine sulphate, chondroitin sulphate, ASU, diacerein, and hyaluronic acid) have symptomatic effects and may modify structure
SYSADOA is a generic term used for symptomatic slow acting drugs for OA, and includes glucosamine sulphate and related compounds, chondroitin sulphate, and diacerein. There is wide variability throughout Europe in the use of these drugs and how they are classified. In the United Kingdom, for instance, they are classified as a health food supplement rather than a prescribable drug, are available only over the counter, and are very widely self administered. Those SYSADOA (for example, glycosaminoglycan polysulphates) that are no longer in use throughout Europe have not been included in this analysis. The other products have been assessed individually.

Both chondroitin sulphate and glucosamine sulphate have been the focus of a meta-analysis, including all studies up to 1999.61 This report concluded that trials of chondroitin and glucosamine compounds demonstrated moderate to large effects on pain and disability in OA compared with placebo; however, these effects may have been exaggerated by publication bias. These products are also safe and associated with few side effects.

In summary, there is evidence to support the efficacy of HA in the management of knee OA both for pain reduction (1B) and functional improvement (1B). However, although pain relief may be obtained for several months, rather than for several weeks as with steroid, this benefit may be offset by its slower onset of action and by the requirement of a course of 3–5 weekly injections with the logistical and cost issues that that entails. There is minimal evidence for a role in disease modification. The term SYSADOA covers a range of agents. There is growing evidence to support the use of two of these agents for their symptomatic effects—namely, glucosamine sulphate (1A) and chondroitin sulphate (1A), but for the others the evidence is weak or absent.

Хондропротекторы, по крайней мере, глюкозами и хондоитин – это лекарства (drugs), которые в некоторых странах доступны только как БАДы, присутствуют в вышецитированном европейском гайде с указанием уровня доказательности.