Дицинон не влияет на обычные показатели гемостаза, дицинон может быть полезен при обильных месячных, но его эффект слабее по сравнению с НПВС или транексамовой кислотой, и как правило проявляется не сразу, а со второго-третьего цикла. Весьма суровым аргументом, ставящим под сомнение результаты нейтрального действия этамзилата в вышеуказанной статье было то, что 11 женщин из 27 (40 ! %) на нем прекратило прием, причем в основном после первого цикла приема:
Eighteen women stopped treatment during the study--11 of the 27 taking ethamsylate, 3 of the 23 taking mefenamic acid, and 4 of the 26 taking tranexamic acid. Eleven of the 18 patients withdrew after the first cycle of treatment. Poor efficacy was given as the reason for withdrawal by five women taking ethamsylate and one woman taking mefenamic acid. Four other women taking ethamsylate, one of three taking mefenamic acid, and three of five taking tranexamic acid described an unwanted event such as nausea, headache, and dizziness as the reason for withdrawing from treatment.
Поэтому у закончивших 3 цикла лечения эффект был не столь внушителен и потерялся...
Для сравнения - одинаковый эффект, но замедленный на этамзилате:
the overall reduction was 20% in the ethamsylate group and 24% in the mefenamic acid group. Compared with pretreatment values, blood loss was significantly less in each of the 3 treatment months in the mefenamic acid group, but only in the second and third months of treatment in the ethamsylate group. However, more women had a clinically useful reduction in blood loss (greater than 40%) in the ethamsylate group. The onset of effect of mefenamic acid was rapid but ethamsylate showed a comparatively greater effect as the trial progressed.
Br J Obstet Gynaecol. 1991 Jul;98(7):707-11.
A comparative study of ethamsylate and mefenamic acid in dysfunctional uterine bleeding.
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