[Dr.Vad]

Уважаемая Ельвина!

Просто наобум выбрал 2 публикации о традиционнейших национальных средствах в лечении инсульта (просто тысячелетиями использующихся): интересно, найдете ли Вы их тоже эффективными согласно результатам?

Am J Chin Med. 2003;31(2):181-90.

Safety and efficacy assessment of chungpyesagan-tang for acute ischemic stroke.

Jung WS, Choi DJ, Cho KH, Lee KS, Moon SK, Kim YS, Bae HS.

Department of Cardiovascular and Neurologic Diseases (Stroke Center) College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea.

Chungpyesagan-tang is one of the most well-known traditional herbal formulations frequently used for treatment of acute stroke in Korea. Therefore, this study aims to assess the clinical safety and efficacy of chungpyesagan-tang on acute ischemic stroke. We recruited acute cerebral infarction subjects within 1 week after onset time. Then, we prescribed chungpyesagan-tang to an Oriental medical treatment group (OM-group) for 2 weeks and enrolled a Western medical treatment group (WM-group) which received only Western biomedical care as a control. In this study, the OM-group was composed of 75 subjects. However, 14 of them dropped out, as two had progressive stroke while 12 complained of diarrhea. Thus, 61 cases were included in the analysis and compared to the 76 cases of the WM-group. The improvement of OM-group was better than that of the WM-group according to the National Institute of Health Stroke Scale (NIHSS), but not by the Modified Barthel Index (MBI).

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Acta Neurol Scand. 2005 Feb;111(2):118-25.

Does Danshen improve disability after acute ischaemic stroke?

Sze FK, Yeung FF, Wong E, Lau J.

Department of Medicine, Changi General Hospital, Singapore.

Objectives: -Danshen, a Chinese herb, has been used as a standard treatment for acute ischaemic stroke in China. This study assesses the quality of all randomized control trials (RCTs) comparing Danshen of any preparation to without Danshen (placebo or other western or herbal medicines), and to evaluate its effectiveness in improving disability. Materials and methods: -Systematic review through literature search in MEDLINE, Cochrane Library, China Biological Medicine Database and others. The main outcome measure is disability improvement on the Chinese National Disability Scale (CNDS) at 2 weeks after intervention. Results -Of 33 Danshen control trials for acute ischaemic stroke identified in the literature, none were placebo-controlled. Eleven RCTs comparing Danshen with one of seven Western and two herbal medicines met the inclusion criteria for review, however, these studies were of poor quality. Compared with the nine medicines, the effect of Danshen was inferior in five trials and not significantly different in another six trials. For the two trials comparing Danshen with Buflomedil, the combined odds ratio (OR) was 0.27 (95% CI: 0.12-0.61) favouring Buflomedil, but the test of homogeneity revealed heterogeneity (P = 0.083). For the two trials comparing Danshen with Naloxone, the combined OR was 0.16 (95% CI: 0.07-0.40) favouring Naloxone. However, none of the nine medicines per se has been proven effective in post-stroke disability improvement. Conclusions -The existing Danshen RCTs are not placebo-controlled and are of poor quality, therefore, there is no substantial evidence that Danshen is effective. Systematic review on RCTs comparing Danshen with other medicines does not support the notion that Danshen may be beneficial to disability improvement after acute ischaemic stroke.

К сожалению, Ваша ссылка не открывается, но в последнее время к отечественным нереферируемым мед. журналам (в них обычно печатаются без экспертной оценки - кто заплатил, того и печатают) отношение крайне сдержанное. А в "Тер. архив" не приняли?
Обычно, критерий впечатляющих достижений в области лечения инсульта - это публикация в "STROKE" (или денег на переводчика не осталось - все пошло на восстановление пациентов после болюсного введения Хуато?).
Зря Вы так на пирацетам или церебролизин - похоже все дело в дозе (пирацетам 5 г в сутки, церебролизин 30 мл при некоторых болезнях-таки "работают").